Comparison of analgesic effects of dexmedetomidine and ketamine in adductor canal block ( for post operative pain relief following unilateral TKR )

Evaluation of analgesic effects of ketamine versus dexmedetomidine as an adjuvant to 0.2% ropivacaine infusion in adductor canal block for post-operative analgesia following unilateral total knee replacement surgery. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062480

Enrollment

Registered

2024-02-09

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Adductor canal block: All patient undergoing unilateral knee replacement will receive 0.2% ropivacaine as an infusion in adductor canal block for post operative analgesia Control Inter

Eligibility

Inclusion criteria

Inclusion criteria: American society of anaesthesiologist physical status I-III

Exclusion criteria

Exclusion criteria: 1) Allergy to local anaesthetics 2) Patient with history of previous knee surgeries 3) Patients with contra indications to spinal anaesthesia 4) Patients with history of chronic analgesic use

Design outcomes

Primary

Measure	Time frame
Number of patients requiring additional opioids following ketamine versus dexmedetomidine as an adjuvant to ropivacaine infusion in adductor canal blockTimepoint: 24 hours post operatively	—

Secondary

Measure	Time frame
1 )Hemodynamic changes 2 ) To assess motor blockade 3 )Pain on ambulation. 4 )To compare adverse effects like hallucination , nausea , vomiting Timepoint: 4th hourly for 24 hours post operatively	—

Countries

India

Contacts

Public ContactDr Sahla Shamsudheen

Amrita institute of medical science and research centre

gokuldas75@hotmail.com9847448005

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026