Health Condition 1: B968- Other specified bacterial agents as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Not applicable as observational study: Not applicable as observational study
Intervention2: NIL: NIL
Control Intervention1: Not applicable as observational study: Not applicable as obse
Sponsors
AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: Admitted to the ICU within 24 hours of having been diagnosed with septic shock. Defined by Sepsis-3 consensus guidelines as a suspected or confirmed source of infection with Sequential organ failure assessment (SOFA) more than or equal to 2 and shock. Shock is defined as hypotension requiring persistent vasopressor therapy to maintain mean arterial pressure (MAP) of more than 65 mmHg and serum lactate levels greater than 2 mmol per L despite adequate initial fluid resuscitation (at least 30ml per kg of IBW).
Exclusion criteria
Exclusion criteria: Patients on short term mechanical ventilation less than 48 hours. A pre-ICU diagnosis of cognitive dysfunction as indicated by their medical records on admission, or a primary central nervous system diagnosis like cerebrovascular accident, meningitis, seizure disorder, psychiatric disorder, hypoxic encephalopathy post cardiac arrest. Death before assessment of ICU-delirium within 3 days of ICU admission. Life-threatening bleeding, the presence of hemorrhagic shock, as judged by research or treating clinicians. Burns, Pregnancy. Referral from or treated at other healthcare facilities. Patients with a likely extracerebral source of serum S100B elevation (e.g., severe disabling neuromuscular disorders, severe burns, advanced malignancy, polytrauma, and chronic renal failure). Readmission to ICU. Withdrawal of consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To analyze the correlation of day-7 cumulative fluid balance with the incidence of delirium, during the first 7 days of ICU admission.Timepoint: From day 1 to day 7 after ICU admission | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the correlation of cumulative fluid balance with the average comatose (RASS -4 and-5) daysTimepoint: From day 1 to day 7 after ICU admission;To assess the correlation of cumulative fluid balance with the average days of delirium (CAM-ICU positive days) Timepoint: From day 1 to day 7 after ICU admission;To assess the correlation of cumulative fluid balance with the severity of delirium using CAM-ICU-7 Delirium Severity ScaleTimepoint: From day 1 to day 7 after ICU admission;To assess the effect of other risk factors of delirium.Timepoint: From day 1 to day 7 after ICU admission;To study the association of cumulative fluid balance with the changes in frontal cortex using fNIRS in patients with delirium.Timepoint: on day1, 4 and 7 after ICU admission | — |
Countries
India
Contacts
Public ContactMeenupriya Arasu
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed