Role of Stem Cells and Platelet Rich Plasma in regenerating uterine lining (endometrium) in women with uterine adhesions and thin endometrium

Role of Autologous Stem Cells and Platelet Rich Plasma Therapy for Regenerating Endometrium in Women with Ashermanâ??s Syndrome and Atrophic Endometrium-A Pilot Study

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062437

Enrollment

Registered

2024-02-08

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N972- Female infertility of uterine origin

Interventions

Intervention1: Subendometrial instillation of Stem cells: This will be planned in the proliferative phase of the cycle under hysteroscopic guidance. All patients will undergo hysteroscopy under local

Eligibility

Inclusion criteria

Inclusion criteria: 1. Women with Ashermanâ??s syndrome that have undergone hysteroscopic adhesiolysis resulting in Normal/optimal cavity size yet atrophic endometrium ( 2. Women with refractory atrophic endometrium ( 3. Willing to participate in the study

Exclusion criteria

Exclusion criteria: 1. Women with Ashermanâ??s syndrome after surgical correction with suboptimal uterine cavity 2. Genital tuberculosis (the disease has profound effects on compromising cavity size, compromising sub-endometrial vascularity and being a pilot work will be selective on cases) 3. Hematologic disorders, hemoglobin level of 4. Chronic autoimmune diseases 5. Refusal to participate in study

Design outcomes

Primary

Measure	Time frame
This study will help in understanding the best strategy to regenerate endometrial lining in patients with refractory Ashermanâ??s syndrome and atrophic endometrium. By having a correlation of percentage of mononuclear and mesenchymal stem cells with the endometrial regeneration will be valuable in planning future studies. The analysis of growth factors in PRP and their effect on endometrial thickness will be of utmost importance for standardization of PRPTimepoint: All the patients will receive standard hormone replacement therapy and followed up at 1 month, 2 months, 3 months and 6 months.	—

Measure

Time frame

This study will help in understanding the best strategy to regenerate endometrial lining in patients with refractory Ashermanâ??s syndrome and atrophic endometrium. By having a correlation of percentage of mononuclear and mesenchymal stem cells with the endometrial regeneration will be valuable in planning future studies. The analysis of growth factors in PRP and their effect on endometrial thickness will be of utmost importance for standardization of PRPTimepoint: All the patients will receive standard hormone replacement therapy and followed up at 1 month, 2 months, 3 months and 6 months.

—

Secondary

Measure	Time frame
â?¢Standardization of PRP preparation â?¢This will open the pathway to future studies with larger sample size â?¢After we have the results and have an idea of best strategy to deal with refractory AS and atrophic endometrium, we can have further studies to evaluate role of PRP and stem cells in IVF cycles and compare with reproductive outcomes.Timepoint: 3 Years	—

Countries

India

Contacts

Public ContactDr NEENA MALHOTRA

AIIMS

malhotraneena@yahoo.com9891557707

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026