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TREATMENT OF INTRABONY DEFECTS USING A-PRF BLOCK WITH OR WITHOUT THE INCORPORATION OF METRONIDAZOLE COMPARED TO MIXTURE OF A-PRF+i-PRF ALONE: A RANDOMIZED CONTROLLED CLINICAL TRIAL

CLINICAL AND RADIOGRAPHIC EVALUATION OF ADVANCED-PLATELET RICH FIBRIN BLOCK WITH AND WITHOUT METRONIDAZOLE INFUSION COMPARED TO A MIXTURE OF A-PRF+ i-PRF ALONE IN THE MANAGEMENT OF PERIODONTAL INTRABONY DEFECTS: A RANDOMIZED CONTROLLED CLINICAL TRIAL - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/02/062436
Enrollment
60
Registered
2024-02-08
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K00-K14- Diseases of oral cavity and salivary glands

Interventions

Intervention1: GROUP B : A-PRF + i-PRF +DFDBA : Following open flap debridement (OFD), mixture of A-PRF + i-PRF + DFDBA will be placed in the intrabony defect. A-PRF and i-PRF will be prepared as e

Sponsors

DR TRUSHA KISHORE PEDNEKAR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Male and female patients with chronic periodontitis 2.With a platelet count within normal limits 3.Presence of atleast one or two sites with probing pocket depth (PPD) of more than 6 mm 4.Three-walled defect with depth of more than 3 mm, as confirmed by cone beam computed tomography (CBCT)

Exclusion criteria

Exclusion criteria: 1.Pregnancy and lactation 2.Smokers and tobacco users 3.Hypertension 4.Diabetes 5.Any other systemic disorders which affect the outcome of the treatment • Patients who are unwilling to participate in the study

Design outcomes

Primary

MeasureTime frame
Defect fill (change in distance from cement enamel junction to Base of defect from baseline to 9 months) will be recorded Defect resolution (change in distance from Alveolar Crest to base of defect from baseline to 9 months) will be recorded Timepoint: baseline and after 9 months

Secondary

MeasureTime frame
Plaque index(PI) Gingival index (GI) Pocket probing depth (PPD) Relative attachment level (RAL) Timepoint: baseline and after 9 months

Countries

India

Contacts

Public ContactTRUSHA KISHORE PEDNEKAR

GOA DENTAL COLLEGE AND HOSPITAL

jamessamueldental@gmail.com98222151608

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026