Health Condition 1: S069- Unspecified intracranial injury
Conditions
Interventions
Intervention1: Profound blockade by Inj VECURONIUM will be reversed with Sugammadex at end of surgery.: Profound blockade by Inj vecuronium Intravenous INFUSION in a dose of 0.03-0.07 MG/KG/HOUR as a
Sponsors
DR SUMEDHA MEHTA
DR KIRTI PAWAR
Eligibility
Inclusion criteria
Inclusion criteria: -PATIENTS UNDERGOING ELECTIVE NEUROSURGICAL PROCEDURE UNDER GENERAL ANESTHESIA WITH SEVOFLURANE REQUIRING MUSCLE RELAXATION. -ASA PHYSICAL STATUS 1,2 AND 3.
Exclusion criteria
Exclusion criteria: 1) DIFFICULT AIRWAY. 2) NEUROMUSCULAR DISORDER THAT COULD IMPAIR NMB. 3) SIGNIFICANT RENAL OR HEPATIC DYSFUNCTION. 4) FAMILY HISTORY OF MALIGNANT HYPERTHERMIA. 5) PATIENTS RECEVING MEDICATIONS,WHICH INTERFER WITH THE NMBA. 6) PATIENTS REQUIRING POST-OPERATIVE VENTILATOR SUPPORT. 7) ALREADY INTUBATED OR TRACHEOSTOMIZED PATIENTS. 8) OBESITY. 9) PATIENT REFUSAL. 10) PREGNANT OR LACTATING WOMEN. 11) ANY ALLERGY TO STUDY DRUG.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2MG/KG DOSE OF SUGAMMADEX IS EFFECTIVE IN REVERSING PROFOUND NEUROMUSCULAR BLOCKADE WITH INFUSION OF ROCURONIUM AND VECURONIUM IN NEUROSURGICAL PATIENTS.Timepoint: TOF MONITORING: -PRIOR TO INDUCTION -IMMEDIATE AFTER INDUCTION -IMMEDIATE AFTER INTUBATION AND AT TIME INTERVAL OF 5 MINUTES -AT THE TIME OF EXTUBATION -5 AND 10 MIN AFTER EXTUBATION | — |
Secondary
| Measure | Time frame |
|---|---|
| ADVERSE EFFECTS ASSOCIATED WITH SUGAMMADEX.Timepoint: INTRA-OPERATIVELY AND POST-OPERATIVELY | — |
Countries
India
Contacts
Public ContactKIRTI SURENDRA PAWAR
SMT KASHIBAI NAVALE MEDICAL COLLEGE,NARHE PUNE
Outcome results
None listed