A Randomized control trial comparing three different group of drugs which can better decrease stress response to putting a tube in patients trachea for proper lung ventilation during general anaesthesia in laparoscopic surgery.

A Randomized Control Trial comparing intravenous magnesium sulphate, dexmedetomidine and labetalol for attenuation of cardiovascular stress response during endotracheal intubation in laparoscopic surgeries. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062361

Enrollment

120

Registered

2024-02-07

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: - Health Condition 3: K802- Calculus of gallbladder without cholecystitis

Interventions

Intervention1: A RANDOMIZED CONTROL TRIAL: A RANDOMIZED CONTROL TRIAL COMPARING INTRAVENOUS MAGNESIUM SULPHATE,DEXMEDETOMIDINE AND LABETALOL FOR ATTENUATION OF CARDIOVASCULAR STRESS RESPONSE DURING EN

Eligibility

Inclusion criteria

Inclusion criteria: 1)American society of anaesthesiologist grade 1 and 2 patients. 2)Patients undergoing elective laparoscopic surgeries.

Exclusion criteria

Exclusion criteria: 1)patients refusal 2)Heart rate 3)systolic blood pressure of 4)Mallampatti grading 3 and 4 5) anticipated difficult intubation. 6)patients with systemic disorders like Left ventricular failure,any degree of heart block,ischemic heart disease,aortic stenosis and bronchial asthama.

Design outcomes

Primary

Measure	Time frame
To monitor change in heart rate during laryngoscopy and endotracheal intubation,and which drug is the best in blunting hemodynamic stress response during endotracheal intubation.Timepoint: T0:Base line HR,BP,Spo2 T1:After induction T2:Before laryngoscopy T3:Immediately after laryngoscopy and intubation T4:2 mins after intubation T5:5mins after intubation T6:Before pneumoperitoneum T7:2mins after pneumoperitoneum T8:5mins after pneumoperitoneum T9:10mins after pneumoperitoneum T10 :Before intubation T11:Immediately after extubation. T12:5mins after extubation.	—

Measure

Time frame

To monitor change in heart rate during laryngoscopy and endotracheal intubation,and which drug is the best in blunting hemodynamic stress response during endotracheal intubation.Timepoint: T0:Base line HR,BP,Spo2 T1:After induction T2:Before laryngoscopy T3:Immediately after laryngoscopy and intubation T4:2 mins after intubation T5:5mins after intubation T6:Before pneumoperitoneum T7:2mins after pneumoperitoneum T8:5mins after pneumoperitoneum T9:10mins after pneumoperitoneum T10 :Before intubation T11:Immediately after extubation. T12:5mins after extubation.

—

Secondary

Measure	Time frame
1)To monitor change in blood pressure during laryngoscopy and intubation. 2)Requirement of analgesic supplementation intraoperatively. 3)Level of sedation at the time of extubationTimepoint: Be will also be recorded along with heart rate. Every 30 mins post intubation . Level of sedation at the time of extubation will be assessed with the help of riker sedation agitation scale.	—

Countries

India

Contacts

Public ContactDr K KARTHIK

SRM medical college hospital and research centre

karthikkrishnamoorthy1981@gmail.com9884360796

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026