Health Condition 1: C189- Malignant neoplasm of colon, unspecified Health Condition 2: C19- Malignant neoplasm of rectosigmoidjunction Health Condition 3: C20- Malignant neoplasm of rectum
Conditions
Interventions
Intervention1: Maintenance of anaesthesia will be done with propofol infusion via same target controlled infusion. The effect site concentration (Ce) will be titrated in every 5 minutes to maintain BI
Sponsors
DR BRAIRCHAIIMS
Eligibility
Inclusion criteria
Inclusion criteria: Patient undergoing surgery for colorectal carcinoma, of ASA grade 1,2,3
Exclusion criteria
Exclusion criteria: 1. Patient refusal, 2. Allergy to propofol or any other drugs included in the study, 3. Chronic liver and kidney disease, 4. Inability to assess postoperative pain (post-operative mechanical ventilation), 5. Inability to understand and use intravenous patient controlled analgesia, 6. Early termination of intravenous patient controlled analgesia (re-do surgery, deterioration of patient status)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| post operative pain scoresTimepoint: at 1 ,2 ,4 ,8 12,16,20,24 hours in the postoperative period | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the incidence of post-operative complications in the two different anaesthesia techniques until the day of discharge using Clavien – Dindo classificationTimepoint: till the day of discharge;To compare the opioid consumption in first 24 hours following surgery via intravenous patient controlled analgesia in both the groupsTimepoint: for first 24 hours;To find out the difference in between peri-operative inflammatory markers: change between preoperative (just before induction) and post- operative (24 hours after surgery) in IL-6, Neutrophil Lymphocyte ratio (NLR) Platelet Lymphocyte ratio (PLR) , Monocyte Lymphocyte ratio ( MLR).Timepoint: preopertaive sample and postoperative day 1 | — |
Countries
India
Contacts
Public ContactDr Ipsita Pati
DR BRA.IRCH AIIMS NEW DELHI
Outcome results
None listed