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A study to understand the healing of gum surgery with enzymes

Assessment of post-surgical healing and patient reported outcomes of adjunctive systemic enzyme therapy after periodontal flap surgery- A randomized clinical trial - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/02/062302
Enrollment
24
Registered
2024-02-06
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K055- Other periodontal diseases

Interventions

Intervention1: Systemic Enzyme Therapy group: After the periodontal flap surgery the participants will be prescribed with systemic enzymes in the form of Phlogam®tablets each providing 90 mg (450 FIP

Sponsors

Garapati Nitya sri
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with persistent probing pocket depths of =5mm in at least four adjacent teeth (Periodontitis Stage II, III and Grade B, C)

Exclusion criteria

Exclusion criteria: 1.Patients who have any active infections i.e., periapical, periodontal or odontogenic lesion 2.Any allergic reactions to the components of the systemic enzyme supplement 3.Severe congenital or acquired coagulation disorders (e.g. hemophilia, in dialysis patients) or liver damage, 4.Pregnancy or breastfeeding, 5.Any clinical signs or laboratory evidence for severe inflammatory, endocrine, renal/pulmonary, neurological, cardiovascular, metabolic, gastrointestinal, hematological, or psychiatric condition 6.Active malignancy of any type 7.Current use of anticoagulants or platelet aggregation inhibitors, chemotherapeutic agents, antibiotics, medication for lipids, diabetes, hypertension, inflammation, autoimmune diseases, mood disorders 8.Use of NSAID within 1 month of entering the study, 9.Alcoholism, smoking, 10.Current use of nutritional supplements

Design outcomes

Primary

MeasureTime frame
Early wound healing score (EHS)Timepoint: T1-7days post surgically T2-14 days post surgically T3-30days post surgically

Secondary

MeasureTime frame
Pain using Visual analog scale (VAS)Timepoint: T1-7 days post surgically T2-14 days post surgically T3-30 days post surgically

Countries

India

Contacts

Public ContactGarapati Nitya Sri

Vishnu Dental college

garapatinityasri@gmail.com8688155211

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026