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Comparison of effect of two drugs used to reverse general anesthesia named sugammadex & neostigmine plus glycopyrrolate on higher mental functions in older adults undergoing hip surgeries

Comparison of sugammadex with neostigmine plus glycopyrrolate combination as a neuromuscular block reversal drug on postoperative cognitive dysfunction in older adults undergoing hip surgeries: a randomised controlled trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/02/062288
Enrollment
50
Registered
2024-02-05
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: M21- Other acquired deformities of limbs

Interventions

Intervention1: effect of sugammadex as a neuromuscular block reversal drug on postoperative cognitive dysfunction in older adults undergoing hip surgeries: effect of sugammadex as a neuromuscular bloc

Sponsors

Shreya Chauhan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Posted for elective hip surgeries under general anesthesia with ASA Physical Status one two three

Exclusion criteria

Exclusion criteria: Any neurological disorder affecting the patients ability to understand the questionnaire Patients with such visual or hearing impairment that it affects the patients ability to read the scale or answer the questions that will be asked Patients taking antidepressants and or tranquilisers Any known allergies to drug being administered Patient refusal

Design outcomes

Primary

MeasureTime frame
To compare the cognitive function using Postoperative Quality of Recovery Scale PQRS at 30min 12hrs 24hrs 72hrs 7th day and 30th day postoperatively from baseline values in patients receiving Sugammadex vs those receiving neostigmine plus glycopyrrolate combinationTimepoint: To compare the cognitive function using Postoperative Quality of Recovery Scale PQRS at 30min 12hrs 24hrs 72hrs 7th day and 30th day postoperatively

Secondary

MeasureTime frame
To assess the hemodynamic adverse effects of sugammadex that is bradycardia and hypotension within 30 mins of its administration. To assess the total intraoperative opioid consumption. To assess the postoperative electrolytes levels within 24hrs.Timepoint: observe for bradycardia after 30 mins of reversal administration observe electrolytes after 24hrs

Countries

India

Contacts

Public ContactDr Shagufta Naaz

AIIMS Patna

drshaguftanaaz@gmail.com7765937919

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026