Comparing the effectiveness of Magnesium Sulfate and Dexmedetomidine in attenuating the stress response to pneumoperitoneum in Laparoscopic Cholecystectomy surgeries under General Anaesthesia

Comparison of the efficacy of Magnesium Sulfate and Dexmedetomedine for attenuation of hemodynamic stress response to pneumoperitoneum in patients undergoing Laparoscopic Cholecystectomy under General Anaesthesia. - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062251

Enrollment

Registered

2024-02-05

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine Magnesium sulfate: Dexmedetomedine 1mcg/kg IV in 100ml Normal saline 15 min before induction followed by 0.2mcg/kg/hr upto peritoneal deflation. Magnesium sulfate 40mg/

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists Physical Status 1 and 2 posted for elective laparoscopic cholecystectomy under general anesthesia

Exclusion criteria

Exclusion criteria: Patients with known cardiac abnormalities, Uncontrolled hypertension & diabetes mellitus, Pregnancy, Morbidly obese, History of allergy to any of the study drugs

Design outcomes

Primary

Measure	Time frame
Stress Response to pneumoperitoneum as measured by increase in Heart Rate and Mean Arterial Blood PressureTimepoint: Baseline, 5 minutes, 15 minutes, 30 minutes and 60 minutes after peritoneal insufflation with CO2, 5 minutes after peritoneal deflation	—

Secondary

Measure	Time frame
adverse effectsTimepoint: intraoperative and post operative periods	—

Countries

India

Contacts

Public ContactDr Annamalai Ramamoorthy

Government Medical College, Kadapa

drsonu818@gmail.com9966844503

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026