A clinical trial comparing pulmonary complications in two routes of gastric conduit placement after esophagectomy

A Phase II Randomised controlled trial comparing pulmonary complications in retrosternal vs posterior mediastinal gastric conduit placement in patients undergoing Esophagectomy - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062245

Enrollment

Registered

2024-02-05

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C158- Malignant neoplasm of overlappingsites of esophagus

Interventions

Intervention1: Surgical: Retrosternal gastric route Intervention2: Surgical: gastric conduit for esophagogastric anastomosis is taken through retrosternal route( intervention arm) for a duration of 6

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with resectable carcinoma esophagus planned for transthoracic esophagectomy after neoadjuvant treatment (NACT/NACTRT) 2. ECOG (Eastern cooperative oncology group) performance status 0 and 1

Exclusion criteria

Exclusion criteria: 1. Locally advanced esophageal cancer deemed unresectable as per MDT discussion 2. Metastatic/Recurrent esophageal cancer 3. Increased pulmonary risk (FEV1 4. Increased cardiac risk (status post myocardial infarction, grade IV NYHA) 5. Intrathoracic anastomosis, and reconstruction with other conduits such as colon and jejunum. 6. History of treatment for previous malignancy. 7. Pregnant or lactating women. 8. Patient refused for consent for the study.

Design outcomes

Primary

Measure	Time frame
To compare the pulmonary complications in post operative period between patients undergoing retrosternal gastric conduit placement vs posterior mediastinal gastric conduit placement.Timepoint: 2 years	—

Secondary

Measure	Time frame
1. To assess the impact of retrosternal and posterior mediastinal gastric conduit placement on postoperative pulmonary function. 2. To investigate the association between route of gastric conduit placement, duration of surgery and length of hospital stay 3. To assess the impact of retrosternal and posterior mediastinal gastric conduit placement on postoperative anastomotic leak rates Timepoint: 2 years	—

Measure

Time frame

1. To assess the impact of retrosternal and posterior mediastinal gastric conduit placement on postoperative pulmonary function. 2. To investigate the association between route of gastric conduit placement, duration of surgery and length of hospital stay 3. To assess the impact of retrosternal and posterior mediastinal gastric conduit placement on postoperative anastomotic leak rates Timepoint: 2 years

—

Countries

India

Contacts

Public ContactAmit kumar

AIIMS NEW DELHI

drsandeepbhoriwal@gmail.com9811104423

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026