Difference in result between white paraffin with oral methotrexate and Siddharthaka Snana ointment with oral Guduchi Ghrita in management of Ekakushtha (Psoriasis)

Evaluation of comparative efficacy of white paraffin with oral methotrexate versus Siddharthaka Snana ointment with oral Guduchi Ghrita in management of Ekakushtha (Psoriasis) - RCT - Nil

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/062171

Enrollment

120

Registered

2024-01-31

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L409- Psoriasis, unspecified

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Patient with Moderate to severe Psoriasis with PASI score more than 10 and willing to participate in the study Patient between the age group of 18 to 50 years of either sex and Prakruti Patient having clinical feature of Ekakushtha that is of Aswedana which means dry and rough lesions Mahavastu which covers the entire body Matsyashakalawat is well demarked raised patches with large silvery loose scaling skin resembles scales of fish and Krishna-Aruna Varnata blackish in color

Exclusion criteria

Exclusion criteria: Chronic cases of Psoriasis more than 5 years. Known case of diabetes cancer AIDS tuberculosis and nervous system renal hepatic endocrine gastrointestinal or pulmonary disease Pregnant or lactating women Subjects with other dermatological infectious conditions Major surgical procedure within 28 days prior to randomization Any condition that in opinion of the Investigator does not justify the patientparticipation in the study

Design outcomes

Primary

Measure	Time frame
To evaluate the efficacy and better result of Siddharthaka Snana ointment with oral Guduchi Ghrita on thebasis of PASI Score To evaluate the efficacy of white paraffin ointment with oral Methotrexate on the basis of PASIScore To compare the efficacy in Siddharthaka Snana ointment with oral Guduchi Ghrita and white paraffin ointment with oral Methotrexate on the basis of PASI ScoreTimepoint: 60 days	—

Measure

Time frame

To evaluate the efficacy and better result of Siddharthaka Snana ointment with oral Guduchi Ghrita on thebasis of PASI Score To evaluate the efficacy of white paraffin ointment with oral Methotrexate on the basis of PASIScore To compare the efficacy in Siddharthaka Snana ointment with oral Guduchi Ghrita and white paraffin ointment with oral Methotrexate on the basis of PASI ScoreTimepoint: 60 days

—

Secondary

Measure	Time frame
To evaluate the efficacy of Siddharthaka Snana ointment with oral Guduchi Ghrita on quality of life through Dermatology life quality index (DLQI) and Psoriasis disability index (PDI) in patient of Psoriasis To evaluate the efficacy of white paraffin ointment with oral Methotrexate on quality of lifethrough DLQI and PDI in patient of Psoriasis To compare the efficacy in Siddharthaka Snana ointment with Guduchi Ghrita and white paraffin ointment with oral Methotrexate on quality of life through DLQI and PDI in patient of PsoriasisTimepoint: 60 days	—

Measure

Time frame

To evaluate the efficacy of Siddharthaka Snana ointment with oral Guduchi Ghrita on quality of life through Dermatology life quality index (DLQI) and Psoriasis disability index (PDI) in patient of Psoriasis To evaluate the efficacy of white paraffin ointment with oral Methotrexate on quality of lifethrough DLQI and PDI in patient of Psoriasis To compare the efficacy in Siddharthaka Snana ointment with Guduchi Ghrita and white paraffin ointment with oral Methotrexate on quality of life through DLQI and PDI in patient of PsoriasisTimepoint: 60 days

—

Countries

India

Contacts

Public ContactDr Sourabh Deshmukh

Mahatma Gandhi Ayurved College Hospital and Research centre

vkuchewar@gmail.com9518954672

Outcome results