A study comparing the effects of dexmedetomidine and lignocaine on changes in heart rate and blood pressure during removal of endotracheal tube in abdominal surgeries

Comparison on the effects of I.V. dexmedetomidine versus I.V. lignocaine on haemodynamic responses during tracheal extubation in abdominal surgeries - NIL

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/062160

Enrollment

100

Registered

2024-01-31

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Infusion Dexmedetomidine: Infusion Dexmedetomidine is given at a doze of 0.5 microgram per kilogram of body weight over a period of 15 minutes before extubation Control Intervention1:

Eligibility

Inclusion criteria

Inclusion criteria: Age 18-45 years in both sex ASA grade 1 and 2 Elective abdominal surgeries

Exclusion criteria

Exclusion criteria: 1. Active upper respiratory infection 2. Known case of drug allergy 3. Patients with respiratory dysfunction and obstructive sleep apnoea 4. Obese patients

Design outcomes

Primary

Measure	Time frame
To determine whether dexmedetomidine or lignocaine is more effective in attenuating haemodynamic responses like heart rate , mean arterial pressure, systolic blood pressure and diastolic blood pressure during extubation in abdominal surgeriesTimepoint: outcomes mentioned above will be measured at 0 mins, 1min, 3 mins, 5 mins, 10 mins, 15 mins , 20 mins , 25 mins and 30 mins	—

Secondary

Measure	Time frame
to compare the effects of dexmedetomidine & lignocaine on extubation qualityTimepoint: to assess the extubation quality score between both the groups from extubation to every 5 minutues upto 30 minutes after extubation	—

Countries

India

Contacts

Public ContactDr Suneeta Dutta

Silchar Medical College and Hospital

drsuneetadutta@gmail.com9435074110

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026