rapid versus slow progression of feeding in less than 34 weeks growth restricted newborns.

Rapid versus slow advancement of feeds in early fed preterm iugr neonates 34 weeks:A randomised control trial - nil

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/062080

Enrollment

Registered

2024-01-30

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P051- Newborn small for gestational age Health Condition 2: P051- Newborn small for gestational age

Interventions

Intervention1: rapid vs slow advancement of feeding.: rapid advancement of feeding @ 25ml/kg/day until 150 ml/kg/day achieved. until full feeds are achieved in newborn Control Intervention1: slow adva

Eligibility

Inclusion criteria

Inclusion criteria: All preterm IUGR neonates less than 34 weeks with birth weight below the 3rd centile on the Intergrowth 21 charts for the gestational age, admitted to the Neonatal Intensive Care Unit.

Exclusion criteria

Exclusion criteria: Exclusion Criteria: The following neonates will be excluded: • Antenatally suspected intestinal anomaly • Lethal congenital anomaly • Dysmorphic or Syndromic baby • Neonates needing invasive ventilation • Inotropic support and on more than 1 ionotrope with instability • History of extensive resuscitation with apgar at 5 min • All babies with surgical conditions. • Twins with evidence of Twin-Twin transfusion. • Intrauterine transfusion or exchange transfusion. • Any evidence of hydrops

Design outcomes

Primary

Measure	Time frame
Estimation of days to attain full feeds defined as 150ml/kg/day in preterm IUGR babies less than 34 weeks fed early where the feeds are rapidly progressed compared to where the feeds are advanced slowly.Timepoint: time to achieve full feeds in rapid group at 6 days vs slow group at 10 days	—

Secondary

Measure	Time frame
The following will be the secondary objectives investigated in the study, wherein the difference in the rapidly progressing group & the slow advancement of feeds will be estimated. Incidence of shock during feeding needing any ionotropic support Incidence of LOS clinical sepsis/ sepsis screen positive / culture positive sepsis Incidence of NEC. Level II & above Incidence of FI. Duration of hospital stay in days Time to regain birth weight All-cause mortality. Timepoint: until 150 ml/kg/day reached or discharge or death	—

Measure

Time frame

The following will be the secondary objectives investigated in the study, wherein the difference in the rapidly progressing group & the slow advancement of feeds will be estimated. Incidence of shock during feeding needing any ionotropic support Incidence of LOS clinical sepsis/ sepsis screen positive / culture positive sepsis Incidence of NEC. Level II & above Incidence of FI. Duration of hospital stay in days Time to regain birth weight All-cause mortality. Timepoint: until 150 ml/kg/day reached or discharge or death

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Countries

India

Contacts

Public Contactdr mukul chauhan

Maulana azad medical college new delhi

neoashish2008@gmail.com9810694789

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026