Health Condition 1: H188- Other specified disorders of cornea
Conditions
Interventions
Intervention1: Topical Insulin Eye Drops: Insulin eye drops will be prepared at a concentration of 1 IU/ml, using regular insulin (rDNA human monocomponent regular insulin 40 IU/ml). The insulin solut
Sponsors
Maulana Azad Medical College, Guru Nanak Eye Center
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients with persistent corneal epithelial defect (due to following etiologies: neurotrophic keratitis, chemical or thermal burns, neuroparalytic, multiple sclerosis, diabetes mellitus, immune mediated, post corneal transplants) of more than 2 weeks duration not responding to conventional treatment 2.Age group more than 18 years. 3.Diabetics and non- Diabetics both
Exclusion criteria
Exclusion criteria: 1.Bacterial or fungal infection on corneal swab 2.Patients with immunosuppressed status eg. HIV, Malignancies 3.Unable to comply with tests/follow-up 4.Lid abnormalities (e.g. entropion, ectropion, trichiasis, etc) 5.Pregnant or breastfeeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete re-epithelisation (percent of people)Timepoint: 1 month | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in best corrected visual acuity (BCVA)Timepoint: 1 month;If complete re-epithelisation not achieved, size of corneal epithelial defectTimepoint: 1 month;Re-epithelialisation time (absence of fluorescein stain) and rate (initial area of PEDmm2/days till re-epithelisation)Timepoint: 1 month | — |
Countries
India
Contacts
Public ContactAvani Hariani
Guru Nanak Eye Center, Maulana Azad Medical College
Outcome results
None listed