Study of comparison of efficacy of dexamethasone and dexmedetomidine to relieve pain after surgery by mixing with local anaesthetics in anterior chest wall nerves block in patient undergoing cardiac surgery

Comparison of analgesic efficacy of dexamethasone and dexmedetomidine as an adjuvant to local anaesthetic in transversus thoracic muscle plane block in adult patient undergoing median sternotomy: A randomized control trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/062035

Enrollment

Registered

2024-01-30

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery Health Condition 2: I060- Rheumatic aortic stenosis Health Condition 3: I069- Rheumatic aortic valve disease, unspecified Health Condition 4: I050- Rheumatic mitral stenosis Health Condition 5: I059- Rheumatic mitral valve disease, unspecified

Interventions

Intervention1: TTMPB + Dexamethasone 8mg: 20 ml 0.25% Bupivacaine + Dexamethasone 8mg Intervention2: Bilateral transversus thoracic muscle plane block + Dexamethasone 8mg: 20 ml 0.25% Bupivacaine + D

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiology physical status : I - III Patients posted for elective open heart surgery via median sternotomy.

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Hypersensitivity, or a history of LA allergies 3. Undergone emergent or redo surgeries 4. Cognitive dysfunction

Design outcomes

Primary

Measure	Time frame
To measure the time to first rescue analgesia post surgery in either of groupsTimepoint: 24 hours post extubation	—

Secondary

Measure	Time frame
1) Total opioid consumption 2) Time to extubation 3) NRS score post extubation 4) Adverse effect of block 5) Patient Satisfaction scoreTimepoint: 1) Total opioid consumption in 24 hours 2) NRS score post extubation at 1 hour, 3 hours, 6 hours, 12 hours, 24 hours. 3) Patient Satisfaction score -24 hour, 48hour	—

Countries

India

Contacts

Public ContactDr Lalit Jha

All India Institute of Medical Sciences

drlalitjha@gmail.com8130917933

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026