To study the effects of different concentrations of Loxicard in reducing the side effects during the removal of breathing tube after operation

Effect of various doses of intravenous Loxicard peri-operatively for blunting the extubation response - A randomised control trial at tertiary care center chengalpattu district - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/062004

Enrollment

165

Registered

2024-01-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J958- Other intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified

Interventions

Intervention1: Lignocaine Hydrochloride 2%: Intravenous 0.5mg/kg STAT dose 10mins duration Intervention2: Lignocaine Hydrochloride 2%: Intravenous 1.5mg/kg STAT dose 10mins duration Control Interventi

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective surgeries under general anaesthesia with endotracheal tube intubation ASA status 1 and 2 BMI between 18.5 AND 29.5

Exclusion criteria

Exclusion criteria: Copd, Restrictive lung disease Hypertensives NYHA Grade 3 AND 4, Patients on beta blockers Asthmatics, Renal Dysfunction Liver Dysfunction History of allergy to study drug and patient refusal

Design outcomes

Primary

Measure	Time frame
Cough assessed with the smoothness of extubation will be graded as follows: Grade 1 : No cough or mild cough only during removal of ETT Grade 2 : Coughing while breathing regularly Grade 3 : Coughing before regular breathing is established. Also occurence of stridor and laryngospasm is noted.Timepoint: Perioperatively (immediately after extubation for 5-10 mins) Baseline	—

Secondary

Measure	Time frame
Cardiovascular changes with extubation are : Haemodynamic parameters such as heart rate, blood pressure(systolic, diastolic, mean arterial pressure)-Baseline, after administration of the study drug , before extubation, every minute after extubation for 5mins & total time taken for extubation- (from discontinuation of inhalational agents to time of endotracheal extubation) Sedation score - Richmond Agitation Sedation Score Pain Score - Visual Analogue ScaleTimepoint: Perioperative :Baseline, after administration of the study drug , before extubation, every minute after extubation for 5mins & total time taken for extubation- (from discontinuation of inhalational agents to time of endotracheal extubation)	—

Measure

Time frame

Cardiovascular changes with extubation are : Haemodynamic parameters such as heart rate, blood pressure(systolic, diastolic, mean arterial pressure)-Baseline, after administration of the study drug , before extubation, every minute after extubation for 5mins & total time taken for extubation- (from discontinuation of inhalational agents to time of endotracheal extubation) Sedation score - Richmond Agitation Sedation Score Pain Score - Visual Analogue ScaleTimepoint: Perioperative :Baseline, after administration of the study drug , before extubation, every minute after extubation for 5mins & total time taken for extubation- (from discontinuation of inhalational agents to time of endotracheal extubation)

—

Countries

India

Contacts

Public ContactDr Blesson john prabhakar R

Shri sathya sai medical college and research institute

drkrishna86@gmail.com9944579455

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026