Effect of oral clonidine vs oral pregabalin as a premedicant on attenuation of hemodynamic response to laryngoscopy and intubation A Randomized drug comparison study

To compare the effect of oral clonidine and oral pregablin on attenuation of hemodynamic response to laryngoscopy and intubation

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061985

Enrollment

102

Registered

2024-01-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: To compare oral clonidine 0.2mg and oral pregabalin 75mg to attenuate stressor response during laryngoscopy and intubation: one group will receive oral clonidine 0.2mg and other group w

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II patients Age between 18 and 65 years patient scheduled for elective surgeries under general anesthesia patient who given written informed consent

Exclusion criteria

Exclusion criteria: ASA III and above patients Patients with baseline heart rate less than 60 beats per minute Pregnant patients Patients on psychiatric medication Patients with known allergy for clonidine and pregabalin Patients not willing to participate in the study

Design outcomes

Primary

Measure	Time frame
To compare the effect of oral clonidine and pregabalin in blunting the stressor during laryngoscopy and intubationTimepoint: 0min 1min 3min 5min 10min	—

Secondary

Measure	Time frame
To assess post operative sedationTimepoint: 24hrs	—

Countries

India

Contacts

Public ContactDR Rajesh Prabhu

Aarupadi veedu medical college and hospital

cr.prabhu@gmail.com9843360106

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026