A Research Study to Evaluate the Effectiveness of a Novel Personalized Electrical Brain Stimulation for the Treatment of Drug-Resistant Focal Epilepsy

Therapeutic Efficacy of Multimodal Imaging-Guided Brain Network Modulation through Personalized, Multisession, High-density Transcranial Direct Current Stimulation in Drug-Resistant Focal Epilepsy: A Double-Blind Sham-Controlled Study - NIL

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061978

Enrollment

Registered

2024-01-29

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G400- Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset

Interventions

Intervention1: Transcranial direct current stimulation (tDCS): Real tDCS protocol: Three cycles (one cycle per two months). Each cycle consisted of 10 sessions (2 weeks x five consecutive days) where

Eligibility

Inclusion criteria

Inclusion criteria: Proven focal onset seizures H/o for at least 2 years refractory to antiepileptic drugs

Exclusion criteria

Exclusion criteria: Pseudoseizures Progressive brain disorders or systemic diseases other than epilepsy Genetic aetiology Patients with implants Change of AEDs during the course of the study Pregnancy

Design outcomes

Primary

Measure	Time frame
1. Continuous monitoring of seizure frequency through a seizure diary 2. Interictal discharge in EEG: 9 sessions (2 sessions - pre-intervention; 4 sessions – Intervention; 3 sessions – post-intervention) Timepoint: 1. Continuous monitoring of seizure frequency through a seizure diary 2. Interictal discharge in EEG (9 sessions): Two sessions – pre-intervention (Day 1 to Day 60) Four sessions – Intervention (Day 61 to Day 240) Three sessions – post-intervention (Day 241 to Day 420)	—

Measure

Time frame

1. Continuous monitoring of seizure frequency through a seizure diary 2. Interictal discharge in EEG: 9 sessions (2 sessions - pre-intervention; 4 sessions – Intervention; 3 sessions – post-intervention) Timepoint: 1. Continuous monitoring of seizure frequency through a seizure diary 2. Interictal discharge in EEG (9 sessions): Two sessions – pre-intervention (Day 1 to Day 60) Four sessions – Intervention (Day 61 to Day 240) Three sessions – post-intervention (Day 241 to Day 420)

—

Secondary

Measure	Time frame
Quality of Life in Epilepsy Inventory: 9 sessions (2 sessions - pre-intervention; 4 sessions – Intervention; 3 sessions – post-intervention)Timepoint: Quality of Life in Epilepsy Inventory (9 sessions): Two sessions – pre-intervention (Day 1 to Day 60) Four sessions – Intervention (Day 61 to Day 240) Three sessions – post-intervention (Day 241 to Day 420)	—

Countries

India

Contacts

Public ContactSuriya Prakash Muthukrishnan

All India Institute of Medical Sciences

dr.suriyaprakash@aiims.edu9650812987

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026