To compare the effectiveness of cold saline wash VS steroid injection in reducing discomfort after wisdom tooth removal.

Efficacy of cooled saline irrigation vs. pre-operative intravenous Dexamethasone in reducing post-operative swelling, pain and trismus after surgical removal of lower impacted third molar: A single center split mouth prospective clinical trial. - NIL

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061963

Enrollment

Registered

2024-01-29

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Cooled saline irrigation: Cooled saline (4 degree C) will be used while bone drilling during wisdom tooth removal. No steroid injection will be administered to patients. Swelling, pain

Eligibility

Inclusion criteria

Inclusion criteria: 1) 18 years or older healthy patients. 2) Bilateral impacted lower third molar needing extraction with the necessity of bone removal based on panoramic radiography. 3) Patients who live within 10km radius of the hospital. 4) Patients who give written consent.

Exclusion criteria

Exclusion criteria: 1) Less than 18 years with comorbidities. 2) Second molars with severe periodontal defect or deep periodontal pocket. 3) Cysts or tumors around the impacted third molar. 4) History of bleeding disorders, smoking, alcoholism and pregnant patients. 5) Patients who live beyond 10 km radius of the hospital. 6) Patients who do not give written consent to participate in the study and follow up.

Design outcomes

Primary

Measure	Time frame
To compare the intensity of post-operative morbidity (pain, facial swelling, and trismus) following surgical removal of lower impacted third molar performed using cooled saline vs. single dose intravenous (IV) Dexamathasone administered pre-operatively.Timepoint: 1. Pre-operative (day 0) 2. Post-operative day 1 3. Post-operative day 3 4. Post-operative day 7	—

Secondary

Measure	Time frame
NATimepoint: NA	—

Countries

India

Contacts

Public ContactDr Srikanth G

Manipal Academy of Higher Education

srikanth.mds@manipal.edu9986455201

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026