To evaluate how oral atenolol as a premedication will affect the hemodynamic changes during the period of pneumoperitoneum in patients undergoing laparoscopic cholecystectomy

Oral Atenolol as premedication in patients undergoing elective laparoscopic cholecystectomy - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061951

Enrollment

100

Registered

2024-01-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K801- Calculus of gallbladder with othercholecystitis Health Condition 2: K00-K95- Diseases of the digestive system

Interventions

Intervention1: oral atenolol as premedicant in patient undergoing elective laprascopic cholecystectomy: 50mg of oral atenolol given to a patient 3 hour prior to surgery then haemodynamic parameters is

Eligibility

Inclusion criteria

Inclusion criteria: 1)patient giving consent 2)ASA physical status 1 and 2 3)patient with BMI between 18 to 24

Exclusion criteria

Exclusion criteria: 1)Patient with contraindication to atenolol (Heart block greater than first degree, pregnant patients, asthma) 2)Coexisting cardio-respiratory disease 3)History of drug allergy, drug intake

Design outcomes

Primary

Measure	Time frame
To evaluate how oral Atenolol premedication will attenuate the hemodynamic changes dur-ing the period of pneumoperitoneum in patients undergoing laparoscopic cholecystectomy.Timepoint: Baseline 1 minute before induction immediately after intubation 5 minutes after intubation 10 minutes after intubation 15 minutes after intubation 20 minutes after intubation 25 minutes after intubation 30 minutes after intubation 45 minutes after intubation 60 minutes after intubation	—

Measure

Time frame

To evaluate how oral Atenolol premedication will attenuate the hemodynamic changes dur-ing the period of pneumoperitoneum in patients undergoing laparoscopic cholecystectomy.Timepoint: Baseline 1 minute before induction immediately after intubation 5 minutes after intubation 10 minutes after intubation 15 minutes after intubation 20 minutes after intubation 25 minutes after intubation 30 minutes after intubation 45 minutes after intubation 60 minutes after intubation

—

Secondary

Measure	Time frame
1.To find the degree of hemodynamic changes that usually occur during insufflation 2)The effect in preventing intubation induced stress response Timepoint: till surgery completed	—

Countries

India

Contacts

Public ContactDr Manisha Bhagat

Rajendra Institute of Medical Sciences,Ranchi

rameshrims02@yahoo.com8294044274

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026