Health Condition 1: K802- Calculus of gallbladder without cholecystitis
Conditions
Interventions
Intervention1: Clonidine: 30 patients will be given intravenous infusion Clonidine, 2 mcg/kg, diluted in 20 ml of normal saline, slowly over 10 minutes before induction
Intervention2: Esmolol: 30 pati
Sponsors
KPC Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adult patients undergoing elective laparoscopic surgery 2. American Society Of Anesthesiologists Grade 1 3. Patients giving Informed Written, Valid consent
Exclusion criteria
Exclusion criteria: 1. Age less than 18 years and more than 45 years 2. Known allergy to anaesthetic agents 3. History of substance abuse and current opioid use 4. Anticipated difficult intubation 5. Duration of laryngoscopy more than 15 seconds 6. Baseline pulse less than 60 beats per minute 7. Baseline systolic blood pressure less than 100 mm Hg 8. Surgery time exceeding 2 hours 9. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary aim of the study is to compare the efficacy of Clonidine and Esmolol in attenuation of hemodynamic stress response due to laryngoscopy and endotracheal intubation.Timepoint: Rate Pressure Product (RPP) will be recorded just after intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary aim of the study is to compare the efficacy of Clonidine & Esmolol in attenuation of hemodynamic stress response during pneumoperitoneum.Timepoint: Rate Pressure Product (RPP) will be recorded 5 minutes after pneumoperitoneum | — |
Countries
India
Contacts
Public ContactDR Debjani Gupta
KPC Medical College & Hospital
Outcome results
None listed