Health Condition 1: C910- Acute lymphoblastic leukemia [ALL]
Conditions
Interventions
Control Intervention1: NIL: NIL since it is an OBSERVATIONAL study.
Sponsors
Other
Eligibility
Inclusion criteria
Inclusion criteria: Test group: Neonates, infants, and children below the age of 12 diagnosed with Acute lymphoblastic leukaemia for the first time. Control group: Age matched children below the age of 12 years without Acute Lymphoblastic Leukemia and having normal developmental milestones.
Exclusion criteria
Exclusion criteria: Test group: Children above the age of 12 years. Children with a previous diagnosis of Acute Lymphoblastic Leukaemia or under treatment. Control group: Children with an active infection. Children with delayed developmental milestones.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Identification of individual metabolites or patterns in metabolites which will serve as a more reliable marker for prognosis of ALL than Absolute Blast Count (ABC). 2. Identification of metabolomic signatures to serve as a predictor for steroid resistance in ALL.Timepoint: Start of the study: Baseline metabolomic signatures of patients and controls will be established. 12 weeks: A pilot data will be generated with a minimum of 10 patient and 10 control samples. 8 months: Completion of sample collection and analysis. 12 months: Generation of the complete data, statistical analysis, generation of the result. | — |
Secondary
| Measure | Time frame |
|---|---|
| Development of a metabolomic pattern as a cheap, reliable alternative for predicting the prognosis and possibility of steroid resistance.Timepoint: 18 months. | — |
Countries
India
Contacts
Public ContactArjun Asok
Manipal Academy of Higher Education, Manipal
Outcome results
None listed