Effects of slow pranayama on the brain

Effects of slow pranayamic breathing on Neural correlates (physiological, psychological, imaging) and cardio-physiological markers in healthy subjects:A Randomized trial - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061907

Enrollment

Registered

2024-01-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Slow breathing pranayama module: Participants will be asked to: 1.Sit in a quiet corner 2.Relax themselves 3.Focus on their breath 4.Keep a mental count of their breath Nadi Shodhana

Eligibility

Inclusion criteria

Inclusion criteria: Healthy adults between 18 to 55 years Education: Secondary or higher Naïve to pranayamic or any yoga practices Willingness to participate

Exclusion criteria

Exclusion criteria: Any contraindications to MRI, including MRI- incompatible implants Regular use of stimulants or any other drug that affects cardiac modulation H/o any systemic illness or psychiatric illness Pregnancy Performs meditation/yoga regularly Claustrophobia

Design outcomes

Primary

Measure	Time frame
To assess the shift in EEG power spectra To assess stress reduction by utilizing the Perceived Stress Scale Timepoint: Baseline assessment and 8 weeks FU	—

Secondary

Measure	Time frame
Changes in fMRI activity (subset of subjects)Timepoint: Baseline assessment and 8 weeks FU;Changes in fMRI connectivity (subset of subjects)Timepoint: Baseline assessment and 8 weeks FU;Changes in structural MRI measures (subset of subjects)Timepoint: Baseline assessment and 8 weeks FU;To assess the changes in scores of STAI scaleTimepoint: Baseline assessment and 8 weeks FU;To assess the changes in the Positive and Negative Affect Scale (PANAS)Timepoint: Baseline assessment and 8 weeks FU;To assess the changes in the Scales of psychological well-beingTimepoint: Baseline assessment and 8 weeks FU;To evaluate changes in beat-to-beat blood pressureTimepoint: Baseline assessment and 8 weeks FU;To evaluate changes in the resting metabolic rateTimepoint: Baseline assessment and 8 weeks FU;To evaluate changes in the skin conductance testTimepoint: Baseline assessment and 8 weeks FU;To evaluate the shift in autonomic nervous system parameters (Holter monitoring)Timepoint: Baseline assessment and 8 weeks FU	—

Measure

Time frame

Changes in fMRI activity (subset of subjects)Timepoint: Baseline assessment and 8 weeks FU;Changes in fMRI connectivity (subset of subjects)Timepoint: Baseline assessment and 8 weeks FU;Changes in structural MRI measures (subset of subjects)Timepoint: Baseline assessment and 8 weeks FU;To assess the changes in scores of STAI scaleTimepoint: Baseline assessment and 8 weeks FU;To assess the changes in the Positive and Negative Affect Scale (PANAS)Timepoint: Baseline assessment and 8 weeks FU;To assess the changes in the Scales of psychological well-beingTimepoint: Baseline assessment and 8 weeks FU;To evaluate changes in beat-to-beat blood pressureTimepoint: Baseline assessment and 8 weeks FU;To evaluate changes in the resting metabolic rateTimepoint: Baseline assessment and 8 weeks FU;To evaluate changes in the skin conductance testTimepoint: Baseline assessment and 8 weeks FU;To evaluate the shift in autonomic nervous system parameters (Holter monitoring)Timepoint: Baseline assessment and 8 weeks FU

—

Countries

India

Contacts

Public ContactDr Gautam Sharma

All India Institute of Medical Sciences

drgautamsharma12@gmail.com01126549326

Outcome results