Health Condition 1: H041- Other disorders of lacrimal gland
Conditions
Interventions
Intervention1: Platelet rich rich plasma injection: Patients own blood will be collected for plasma formulation and injected in to the gland.
The dose is 0.5 to 1cc. Frequency is once in 2 weeks. Rout
Sponsors
L V Prasad Eye Institute
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged 18–70 years 2. Have OSDI scores =33 or Oxford staining grade =2 3. Have a best corrected visual acuity (BCVA) in both eyes of +0.7 logMAR 4.Diagnosis of DED in both eyes supported by the criteria mentioned below Defined by at least one eye meeting all the following criteria: o A symptom severity score of =22 for OSDI o An unanesthetized Schirmer Tear Test (STT) score of =1 mm and =5 mm per 5 minutes o Evidence of ocular surface staining (total fluorescein staining score of at least 3) [0-15 scale]) 5. Have normal lid anatomy and no other ocular disease except refractive errors or cataract
Exclusion criteria
Exclusion criteria: 1. Uncontrolled systemic diseases, active infection or chronic kidney disease, liver cirrhosis, advance cancer. 2. Pregnant or nursing women. 3.Have not recently used the following medications, interventions, surgery, Anticoagulants or anti-platelets,Topical undiluted blood products within 3 months, Punctal plug or contact lenses, Ocular surgery within 6 months. 4.Have no contraindication for blood donation, Positive HIV, hepatitis B or C, or syphilis, Anaemia.Hemoglobin less than 110 grams per Litre.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean change from baseline in total corneal stainingTimepoint: week 4, week 12 | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean change from baseline in the score of dry eye questionnaires, change in Schirmer values & NIBUT, degree of burning or stinging sensationTimepoint: week 4, week 12 | — |
Countries
India
Contacts
Public ContactDr Swati Singh
L V Prasad Eye Institute
Outcome results
None listed