It is to compare the effects of ketofol and propofol as anaesthetic induction agent in patients undergoing supratentorial surgery.

Comparison of ketofol and propofol as anaesthetic induction agent in patients undergoing supratentorial surgery. - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061850

Enrollment

Registered

2024-01-25

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G939- Disorder of brain, unspecified Health Condition 2: 4- Measurement and Monitoring

Interventions

Intervention1: Ketofol: Standardized anaesthesia protocol will be followed. In ketofol group drug will be prepared in 20ml syringe by adding 5ml ketamine and 15ml of propofol. Preoxygenation will be d

Eligibility

Inclusion criteria

Inclusion criteria: Forty four patients of either sex in the age group 18-60 years belonging to ASA 1&2 scheduled to undergo elective supratentorial craniotomies with full GCS, size of lesion less than 5cm & midline shift less than 5mm under general anaesthesia will be enrolled in the study.

Exclusion criteria

Exclusion criteria: The patients with refusal for study, hypertension, obesity, psychiatric disorder, pregnancy, lactation, other methods of brain relaxation being used or planned such as EVD will be excluded from the study.

Design outcomes

Primary

Measure	Time frame
Changes in mean arterial pressure in both groupsTimepoint: 1.At Baseline 2. 2 mins after induction 3. 3 mins after intubation 4. 5 mins after intubation 5. 10 mins after intubation 6. 3 mins after skull pin insertion 7. 5 mins after skull pin insertion 8. at the time of skin incision 9. At the time of bone flap removal 10. At the time of dural opening 11. At the time of skin suturing 12. 5 mins after extubation	—

Measure

Time frame

Changes in mean arterial pressure in both groupsTimepoint: 1.At Baseline 2. 2 mins after induction 3. 3 mins after intubation 4. 5 mins after intubation 5. 10 mins after intubation 6. 3 mins after skull pin insertion 7. 5 mins after skull pin insertion 8. at the time of skin incision 9. At the time of bone flap removal 10. At the time of dural opening 11. At the time of skin suturing 12. 5 mins after extubation

—

Secondary

Measure	Time frame
1. Changes in heart rate 2. Brain relaxation score 3. Pain on injection 4. Myoclonic movements 5. Any adverse events or complications in both the groupsTimepoint: 1.At Baseline 2 mins after induction 3 mins after intubation 5 mins after intubation 10 mins after intubation 3 mins after skull pin insertion 5 mins after skull pin insertion at the time of skin incision At the time of bone flap removal At the time of dural opening At the time of skin suturing 5 mins after extubation 2. After dural opening 3.On administering the induction drug 4. On administering the induction drug 5. After extubation	—

Measure

Time frame

1. Changes in heart rate 2. Brain relaxation score 3. Pain on injection 4. Myoclonic movements 5. Any adverse events or complications in both the groupsTimepoint: 1.At Baseline 2 mins after induction 3 mins after intubation 5 mins after intubation 10 mins after intubation 3 mins after skull pin insertion 5 mins after skull pin insertion at the time of skin incision At the time of bone flap removal At the time of dural opening At the time of skin suturing 5 mins after extubation 2. After dural opening 3.On administering the induction drug 4. On administering the induction drug 5. After extubation

—

Countries

India

Contacts

Public ContactDr Diksha Gulia

Pt. B. D. Sharma PGIMS

diksha.gulia.0@gmail.com7357220096

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026