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This study is intended to find out which dose of Atracurium produces better quality of muscle relaxation - 0.75 mg/kg or 1 mg/ kg

A prospective randomized Non-inferiority study to compare the quality of muscle relaxation using two different doses of Atracurium in patients under general anaesthesia at SMS Medical College, Jaipur - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/01/061812
Enrollment
160
Registered
2024-01-24
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Inj Atracurium at a dose of 0.75 mg/kg: Inj Atracurium at a dose of 0.75 mg/kg is given after induction to achieve good intubating conditions without using a priming dose and compare fo

Sponsors

Department of Anaesthesiology, Sawai Man Singh Medical College and Attached Hospitals
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing surgery under general anaesthesia, with BMI 18.5 to 24.9 and ASA grades 1 and 2

Exclusion criteria

Exclusion criteria: Patients with cardiovascular comorbidities, jaundice, bronchial asthma, epilepsy, uncontrolled diabetes mellitus or hypertension, metabolic or endocrine disease, morbid obesity or any chronic illness or allergy to study drug.

Design outcomes

Primary

MeasureTime frame
Quality of muscle relaxation assessed by disappearance of all four twitches.Timepoint: 12 second intervals - from the time of induction of anaesthesia until all four twitches disappear.—

Secondary

MeasureTime frame
Duration of muscle relaxationTimepoint: Every 5 minute interval till the occurrence of two twitches;Haemodynamic parameters (HR, SBP, DBP, MAP)Timepoint: Baseline, before and after endotracheal intubation, 5 min, 10 min, 15 min 20 min, 25 min, 30 min, till extubation—

Countries

India

Contacts

Public ContactAbhirami J K

Sawai Man Singh Medical College and Attached Hospitals

kanchan2371@yahoo.com8107872222

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026