Health Condition 1: O- Medical and Surgical Health Condition 2: K318- Other specified diseases of stomach and duodenum
Conditions
Interventions
Intervention1: Targeted mean arterial pressure (MAP) management: After baseline MAP is obtained, propofol or fentanyl will be used to reduce and nor epinephrine infusion to maintain the MAP with the
Sponsors
Amrita institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: ASA II and above patients above 45 years with one of the following 1. Coronary artery disease 2. NIDDM 3. cerebrovascular accident 4. peripheral vascular disease undergoing major abdominal surgery lasting more than 4 hours
Exclusion criteria
Exclusion criteria: 1.emergency surgery 2.Preoperative ventilation or COPD 3.Renal dysfunction creatinine more than 1.5 4.CAD EF less than 35% 5.AST ALT more than twice normal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Any organ dysfunction 24 hours postoperatively 1 Renal as per RIFLE criteria 2 Elevated hsTropT 3 Respiratory SpO2 less than 94 or need for respiratory assist devices 4 Neurological GCS less than 14 5 Coagulation Platelet INR as per SOFATimepoint: 24 hours postoperatively in the ICU | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of ICU stay Length of hospital stay SOFA scoresTimepoint: SOFA during IU stay only | — |
Countries
India
Contacts
Public ContactDrMadhubala Venkatesan
Amrita Institute of Medical Sciences
Outcome results
None listed