A clinical study to study the effects of a anaesthetic agent -ketamine and a steroid medication - dexamethasone as an adjunct to local anaesthesia in view of management of pain, swelling and reduced mouth opening in the surgical removal of third molar of lower jaw

Efficacy of Lignocaine with 1:200,000 Adrenaline (LA) vs LA plus Ketamine vs LA plus Dexamethasone in the surgical removal of impacted mandibular third molar - an interventional double blinded study

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061798

Enrollment

Registered

2024-01-24

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: LA + Ketamine: Lignocaine plus Ketamine (0.3MG/KG) injection will be given once during the procedure. The intervention will not be repeated. Intervention2: LA + Dexamethasone: Lignocain

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients aged between 18-50 years 2. Patients with impacted mandibular third molars having a Pederson difficulty index of 5 requiring removal of the same 3. Patients classified as American Society of Anaesthesiologist (ASA) Physical Status 1 4. Patients who understand and are willing to follow all study procedures

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
As the principal investigator, I will be studying Lignocaine with 1;200,000 VS LA + Dexamethasone vs LA + Ketamine as a perineural block post surgical removal of impacted mandibular third molar. Pain, swelling and trismus will be anticipated. Study of LA vs LA + Dexamethasone vs LA + Ketamine will be done to see the reduction in post operative complications.Timepoint: At day 1, day 2 and day 7	—

Secondary

Measure	Time frame
Post surgical pain, swlling and trismus will be assessed.Timepoint: Participant will be recalled after 3 months and SOS as well.	—

Countries

India

Contacts

Public ContactDr Sushant Pawar

Manipal college of dental sciences, mangalore

dharnappa.poojary@manipal.edu9901725285

Outcome results