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Biomarkers in Breast Cancer-microRNA profiling and Omics analysis

MOLECULAR PROFILING OF MICRORNAS AS BIOMARKERS IN BREAST CANCER-INTEGRATED OMICS ANALYSIS IN TERTIARY CARE HOSPITAL - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/01/061792
Enrollment
120
Registered
2024-01-24
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C50- Malignant neoplasm of breast

Interventions

Intervention1: Nil: Nil Control Intervention1: Nil: Nil

Sponsors

Government Mohan Kumaramangalam Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Consecutive patients with newly detected breast cancer- planned for surgery (MRM or BCT) or Neo-adjuvant chemotherapy 2. Age and sex-matched subjects without breast cancer

Exclusion criteria

Exclusion criteria: 1. Known case of Breast cancer previously treated with surgery, chemotherapy or radiotherapy 2. Previous history of treatment for non-breast cancer 3. Patients with unsound mind 4. Patients not willing

Design outcomes

Primary

MeasureTime frame
1. Diagnostic microRNA in breast cancer patients versus healthy adults such as miR-16, miR-19b, miR-106a, miR-21, miR-1246, miR-939, miR-373, miR-101, miR155, let-7 family of miR125b, miR100, miR34a, miR-335 2. Prognostic microRNA in Breast Cancer such as miR-16, miR-19b, miR-106a, miR-21, miR-1246, miR-939, miR-373, miR-101, miR155, let-7 family of miR125b, miR100, miR34a, miR-335Timepoint: 1. Early Breast Cancer Before Surgery Before Adjuvant Chemotherapy Before Adjuvant Radiotherapy 3-month post-chemoradiotherapy 2.Locally Advanced Breast cancer Before neoadjuvant therapy Before Surgery Before Adjuvant Chemotherapy Before Adjuvant Radiotherapy 3-month post-CRT 3. Metastatic Breast Cancer Before and after palliative therapy—

Secondary

MeasureTime frame
microRNA (miR) profile- Early BC markers-miR-16 and miR-106a, a miR-19b-based 3-circulating miRNA miR profile - Invasive Breast Cancer-miR-12, miR-1246 miR profile- Triple negative breast cancer-miR-939 miR profile- Drug resistance - miR-451, miR-326, miR- 100, miR-222, and miR- 30a miR profile- Poor prognosis- miR-155, miR-21, miR-1246, miR-let 7 family miR profile- Diagnostic versus Prognostic markers- miR 155, miR-let 7 family Timepoint: 1. Early Breast Cancer Before Surgery Before Adjuvant Chemotherapy Before Adjuvant Radiotherapy 3-month post-chemoradiotherapy 2.Locally Advanced Breast cancer Before neoadjuvant therapy Before Surgery Before Adjuvant Chemotherapy Before Adjuvant Radiotherapy 3-month post-CRT 3. Metastatic Breast Cancer Before and after palliative therapy—

Countries

India

Contacts

Public ContactPoongkodi Karunakaran

Government Mohan Kumaramangalam Medical College

poongkodithesurgeon@gmail.com9443119743

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026