A comparative study of two surfactant administration techniques

Comparative evaluation of surfactant administration techniques Less Invasive Surfactant Administration (LISA) vs. Intubation Surfactant Extubation (InSurE) in Preterm Infants with Respiratory Distress Syndrome: A randomized control study - nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061707

Enrollment

Registered

2024-01-22

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P220- Respiratory distress syndrome of newborn

Interventions

Intervention1: Less Invasive Surfactant Administration (LISA) technique: Surfactant(Neosurf) will be administered. Dose will be calculated as 5ml/kg. A 5 Fr feeding tube/Surfcath will be placed in the

Eligibility

Inclusion criteria

Inclusion criteria: Preterm infants less than 36 weeks which are fulfilling the criteria for RDS and are spontaneously breathing

Exclusion criteria

Exclusion criteria: Preterm neonates with Anatomical abnormalities of upper airway Congenital Diaphragmatic hernia Choanal atresia Trachea-oesophageal fistula Cleft palate - Requiring intubation with invasive ventilation

Design outcomes

Primary

Measure	Time frame
Efficacy of LISA technique over InSurETimepoint: At 12 hours, 72 hours, throughout the study time period	—

Secondary

Measure	Time frame
Need for mechanical ventilationTimepoint: within 72 hours of birth;need for two or more doses of surfactantTimepoint: within 12 hours of birth	—

Countries

India

Contacts

Public ContactDr Rajeev Kumar Thapar

School of Medical Sciences and Research

rajeev.thapar@sharda.ac.in9839448248

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026