Health Condition 1: F332- Major depressive disorder, recurrent severe without psychotic features
Conditions
Interventions
Intervention1: Electroconvulsive Therapy: Total 12 ECT Sessions
6 ECTs - Twice A Week
Rest ECTs - Once A Week
With Prescribed Medications As Advised
Control Intervention1: Oral Ketamine: 125 - 175 Mg
Sponsors
Department of Psychiatry Sion hospital
Eligibility
Inclusion criteria
Inclusion criteria: All patients above 18 years of age. Patients diagnosed with MDD and not better with medications. Patients requiring ECT.
Exclusion criteria
Exclusion criteria: Patient not willing to give consent. Pregnant and Lactating woman. Patients having contraindications for ECT and Ketamine. Patients with comorbid substance use except Nicotine. Patients who have received either ECT or ketamine during the past 6 months. Patients with a history of non-responsiveness to ECT or ketamine. Patients with any condition that is known to be associated with cognitive impairment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ECT Has More Neurocognitive Side Effects Than KetamineTimepoint: Baseline, 1 Week Post Treatment Endpoint, 1 Month Post Treatment Endpoint | — |
Secondary
| Measure | Time frame |
|---|---|
| To Check How Much Less Neurocognitive Side Effects Does Ketamine Have As Compared To ECTTimepoint: Baseline, 1 Week Post Treatment Endpoint, 1 Month Post Treatment Endpoint | — |
Countries
India
Contacts
Public ContactHeli Yogesh Shah
Lokmanya Tilak Municipal Medical College And General Hospital
Outcome results
None listed