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Development of a prediction tool for kidney injury in patients with respiratory disorder on different ventilation techniques.

Development and validation of a prediction tool for acute kidney injury in spontaneous Vs controlled ventilation patients with moderate to severe acute respiratory distress syndrome - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/01/061610
Enrollment
100
Registered
2024-01-18
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N178- Other acute kidney failure

Interventions

Intervention1: Nil: Nil Control Intervention1: Nil: Nil

Sponsors

Faculty SEED grant- Manipal Academy of Higher Education
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ARDS patients who receive either oxygen therapy, non-invasive ventilation or invasive ventilation (endotracheal or tracheostomy) within the first 24 hours of diagnosis. Patients should have an acute decrease in ratio of partial pressure of arterial oxygen to fraction of inspired oxygen of less than or equal to 200. Evidence of bilateral pulmonary infiltrates on a chest radiograph consistent with ARDS C-reactive protein levels less than 50mg per L Bedside ultrasonogram confirming normal kidneys on admission.

Exclusion criteria

Exclusion criteria: No past history of kidney injury, obstructive nephropathy, pyelonephritis, circulatory shock requiring vasopressors, cardio-respiratory arrest or IV contrast which can contribute to AKI. No history of nephrotoxic drugs for the past 2 weeks Patients with any mode of ventilation less than 24 hours received from outside hospital.

Design outcomes

Primary

MeasureTime frame
Prevalence of acute kidney injury among spontaneous or controlled ventilation patients with ARDSTimepoint: Blood and urine samples will be collected within 12-24 hours of time of admission—

Secondary

MeasureTime frame
To determine the feasibility of using the inflammatory and urinary biomarkers for predicting acute kidney injury in moderate to severe ARDS patients who are on spontaneous or controlled ventilation and develop a prediction toolTimepoint: 12-24 hours of admission—

Countries

India

Contacts

Public ContactVishal Shanbhag

Kasturba Medical College, Manipal Academy of Higher Education, Manipal

vishal.shanbhag@manipal.edu9901960496

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026