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To find out the effectiveness of collagen cross-linking using individualized fluence settings based on each patients corneal thickness in patients of keratoconus with thin cornea.

To evaluate the efficacy of collagen cross-linking with individualized fluence (sub 400 protocol) in keratoconus patient with ultrathin cornea. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/01/061566
Enrollment
25
Registered
2024-01-18
Start date
Unknown
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Collagen Crosslinking using individualized fluence: In this study, the algorithm of Collagen crosslinking will be used to individualize irradiation settings based on each patient’s mini

Sponsors

Dr Parul Jain
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Cases of keratoconus with epithelium-on corneal stromal thickness of < 400µm.

Exclusion criteria

Exclusion criteria: 1. Active and severe vernal keratoconjunctivitis/Atopic keratoconjunctivitis 2. Previous keratitis/corneal scars 3. Pregnancy or lactating women 4. Preexisting ocular trauma 5. Previous ocular surgeries

Design outcomes

Primary

MeasureTime frame
Change in maximum keratometry (Kmax)Timepoint: 1 year—

Secondary

MeasureTime frame
Change in Best Corrected Visual Acuity (BCVA)Timepoint: 1 year;Demarcation line on Anterior Segment OCT (ASOCT)Timepoint: 1 month;Endothelial cell countTimepoint: 1 year—

Countries

India

Contacts

Public ContactDr Parul Jain

Maulana Azad Medical College

pjain811@gmail.com9971927902

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026