Health Condition 1: K859- Acute pancreatitis, unspecified
Conditions
Interventions
Intervention1: Aggressive Endoscopic Necrosectomy: Patients randomized to this group will undergo endoscopic necrosectomy in the same session with index endoscopic drianage procedure. After immediate
Sponsors
Postgraduate Institute of Medical Education and Research PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients of AP with >12 years of age AND 2. Patients with infected peri-pancreatic necrosis (ANC or WON) amenable for EUS guided transluminal drainage 3. Size of infected collection should be more than 10 cm in size with more than 30 % of necrosis as evident on transabdominal ultrasound.
Exclusion criteria
Exclusion criteria: 1. Patients with multiple necrotic collections 2. Collection is not amenable for EUS guided drainage 3. Patients moribund to undergo endoscopic procedure (Glasglow coma scale 4. Patients with underlying calcific pancreatitis 5. Patients with previous history of intervention (endoscopic/percutaneous/surgical) in the collection prior to screening 6. Patients with irreversible coagulopathy like platelets 1.5 7. Pregnant female
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of reinterventions (endoscopic, percutaneous or surgical) required after index drainage procedure to achieve clinical success till 3 months of follow up.Timepoint: 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Time for resolution of SIRS/Organ failure from index procedureTimepoint: 3 months;New onset SIRS/organ failure after index procedureTimepoint: 3 months;Procedure related complications as per ASGE- Lexicon guidelinesTimepoint: 3 months;Requirement of Re-hospitalization till clinical successTimepoint: 3 months;Total hospitalisation days after index procedure till clinical successTimepoint: 3 months;Mortality due to basic disease and its complicationsTimepoint: 3 months | — |
Countries
India
Contacts
Public ContactSanish Ancil
Postgraduate Institute of Medical Education and Research (PGIMER)
Outcome results
None listed