PRP vs HA in osteoarthritis knee: which one is better for your knee ?

Comparison Of Ultrasound Guided Intraarticular Injection Of Platelet Rich Plasma Versus Hyaluronic Acid In Improving Cartilage Thickness And Physical Functions In Patients With Primary Osteoarthritis Of Knee: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061459

Enrollment

Registered

2024-01-15

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: Platelet rich plasma : 4ml of Platelet rich plasma will be given once intraarticularly to the affected knee under ultrasound guidance Control Intervention1: Hyaluronic Acid: 6ml of high

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age group 40 to 65 years 2. Patients with primary knee osteoarthritis fulfilling 2016 ACR(American college of Rheumatology) revised criteria for early diagnosis of knee osteoarthritis(clinical and radiographic) 3. Osteoarthritis of knee with Kellgren-Lawrence grade upto 3 4. Willingness to participate in the study and comply with treatment and follow up 5.VAS >4

Exclusion criteria

Exclusion criteria: 1. Recent knee trauma or knee surgery 2. Knee deformity or knee infection 3. Metabolic disease of bone 4. Cognitive impairment 5. Uncontrolled diabetes mellitus 6. Thrombocytopenia(Platelet count 7. Intraarticular steroid injection during past 3 months 8. BMI >30

Design outcomes

Primary

Measure	Time frame
Knee cartilage thickness assessment by MSK ultrasoundTimepoint: Baseline, 3 month, 6 month and 9 month	—

Secondary

Measure	Time frame
VAS score, WOMAC scoreTimepoint: Baseline, 3 month, 6 month & 9 month	—

Countries

India

Contacts

Public ContactSumit Debnath

Regional Institute of Medical Sciences, Imphal, Manipur

dr.romi.singh@gmail.com9436025822

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026