Dose determination of vitamin C in oral submucous fibrosis

Evaluation Of Dose Dependent Efficacy Of Antioxidant, Vitamin C In Relation To Oxidative Stress Level In Subjects With Oral Submucus Fibrosis - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061369

Enrollment

120

Registered

2024-01-11

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K135- Oral submucous fibrosis Health Condition 2: Z768- Persons encountering health services in other specified circumstances

Interventions

Intervention1: Vitamin C according to oxidative stress level: Single dose Conventional therapeutic dose prescribed dose 500 mg Double dose Two times conventional therapeutic dose 1000 mg 500 mg

Eligibility

Inclusion criteria

Inclusion criteria: Patients above the age of 18 years clinically diagnosed as Oral Submucous Fibrosis, diagnosed on the basis of following clinical parameters. 1) Stomatitis, burning sensation 2) Inter incisal distance

Exclusion criteria

Exclusion criteria: 1. Subjects on any other treatment modalities for Oral Submucous Fibrosis for last 6 months. 2. Subjects with past history of and/or on medication for any systemic and metabolic disorders, psychiatric or dermatologic diseases. 3. Pregnant or lactating mothers.

Design outcomes

Primary

Measure	Time frame
study will give direction for choosing best suitable dose of antioxidant Vitamin C for OSMF depending on oxidative stress level.Timepoint: 6months	—

Secondary

Measure	Time frame
efficacy of low & high dose vit.C in low & high oxidative stress level.Timepoint: 6months	—

Countries

India

Contacts

Public ContactShraddha Patel

Sharad Pawar Dental College and Hospital

vidyalohekadu@gmail.com9960445040

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026