Role of Prednisolone (drug) in Steroid (drug) Responsive Severe Alcoholic Hepatitis(liver disease).

Role of Extended Low Dose Prednisolone in Achieving Clinical and Biochemical Remission in Steroid Responsive Severe Alcoholic Hepatitis. - NIL

Status

Recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061345

Enrollment

150

Registered

2024-01-10

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K758- Other specified inflammatory liverdiseases

Interventions

Intervention1: Extended Steroid Therapy: 10mg of prednisolone plus standard medical therapy for 60 days. Standard Medical Treatment - IV Albumin, Diuretics, Multi vitamins as per clinicians decision C

Eligibility

Inclusion criteria

Inclusion criteria: 1. Persistence of mDF > 32 at day 28 of steroids

Exclusion criteria

Exclusion criteria: 1. Active infection 2. Uncontrolled sugars 3. No consent

Design outcomes

Primary

Measure	Time frame
To assess the proportion of steroid responsive SAH patients achieving remission by extended low dose Prednisolone (10mg/day) till day 90 in comparison to SMTTimepoint: 90 days	—

Secondary

Measure	Time frame
90 day readmission ratesTimepoint: 90 days;New onset infections, diabetesTimepoint: 90 days;To assess the effect of extended low dose steroids in steroid responsive SAH on CTP, MELD-Na, DFTimepoint: 90 days;To assess the effect of extended low dose steroids in steroid responsive SAH on transplant free survivalTimepoint: 90 days	—

Countries

India

Contacts

Public ContactDr Shasthry S M

Institute of Liver and Biliary Sciences

shasthry@gmail.com01146300000

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026