To compare the effect of two drugs dexmedetomidine and lignocaine on decreasing cough response after anaesthesia in patients undergoing surgery for brain tumors.

Comparison of Intratracheal Dexmedetomidine versus Lignocaine on Attenuating Emergence Cough Response to Extubation in Patients Undergoing Craniotomy for Intracranial Tumour: A Multi-Arm Randomized Controlled Trial - RCT

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061334

Enrollment

Registered

2024-01-10

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine Group: ?Injection Dexmedetomidine (0.5 mcg/kg) diluted with 0.9% normal saline to make a volume of 5 ml will be instilled intratracheally into the endotracheal tube 15-2

Eligibility

Inclusion criteria

Inclusion criteria: ASA I or II class, BMI less than 30, Undergoing elective craniotomy for intracranial tumor under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1. Patient Refusal 2. Renal impairment 3. Cardiorespiratory abnormalities 4.Bronchial asthma COPD 5. Restrictive lung diseases 6. Liver failure 7. Allergy to drugs will be used 8. Pregnancy-lactation

Design outcomes

Primary

Measure	Time frame
1.To compare the effect of intratracheal dexmedetomidine and intratracheal lignocaine on the emergence cough response by using the emergence cough scoreTimepoint: 5 min after extubation	—

Secondary

Measure	Time frame
Hemodynamic parameters Heart rate,Mean blood pressure, and Oxygen saturationTimepoint: Baseline (T0) 15 min before extubation (at the time of intervention drug given) (T1) 10 min before extubation (T2) 5 min before extubation (T3) At the time of extubation (T4) 5 min after extubation (T5) 10 min after extubation (T6) 30 min after extubation (T7);VAS scoreTimepoint: 1 hr after extubation, 2 hrs after extubation, and 12 hrs after extubation	—

Measure

Time frame

Hemodynamic parameters Heart rate,Mean blood pressure, and Oxygen saturationTimepoint: Baseline (T0) 15 min before extubation (at the time of intervention drug given) (T1) 10 min before extubation (T2) 5 min before extubation (T3) At the time of extubation (T4) 5 min after extubation (T5) 10 min after extubation (T6) 30 min after extubation (T7);VAS scoreTimepoint: 1 hr after extubation, 2 hrs after extubation, and 12 hrs after extubation

—

Countries

India

Contacts

Public ContactShipra Verma

Uttar Pradesh University of Medical Sciences, Saifai,Etawah

lamhe.17@gmail.com9458657706

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026