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Which drug is better in treatment of headache after caesarean section under spinal anaesthesia

Efficacy of nebulised Dexmedetomidine verses Aminophylline for treatment of Post dural puncture headache in patients undergoing Subarachnoid block posted for caesarean section - A double blind randomized control study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/01/061322
Enrollment
96
Registered
2024-01-10
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O9A2- Injury, poisoning and certain other consequences of external causes complicating pregnancy, childbirth and the puerperium

Interventions

Intervention1: PDPH: Dexmedetomidine and aminophylline nebulisation Intervention2: Dexmedetomidine Nebulization: Ultrasonic Nebulization of 1mcg/kg Dexmedetomidine diluted in 4ml 0.9% Normal saline 12

Sponsors

All India Institute of Medical Sciences Patna
Lead Sponsor
AIIMS Patna Bihar India
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: All Postoperative Caesarean Section Patients Fulfilling Post Dural Puncture Headache Criteria VAS score greater than 4 Lybecker Score greater than 2 ASA PS I and II BMI less than 35

Exclusion criteria

Exclusion criteria: Patient refusal Hypertensive Disorders of Pregnancy Pre existing Cardiac Arrhythmias History of chronic headache, migraine, convulsions and cerebrovascular accident

Design outcomes

Primary

MeasureTime frame
Pain intensity by VAS score and Lybecker scoreTimepoint: 0 Hour 24 Hours 36 Hours 72 Hours

Secondary

MeasureTime frame
Overall treatment responses based on 7- point Likert scaleTimepoint: After 72 Hours

Countries

India

Contacts

Public ContactNeeraj Kumar

AIIMS, Patna

neeraj.jlnmc@gmail.com8210104972

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 27, 2026