Skip to content

To study whether the addition of lignocaine, a local anesthetic (pain relieving) drug, to steroid which is being given by direct injection into the joint have any benefit in cases of arthritis.

Comparison of Intra-articular corticosteroids with and without intra articular local anesthesia in patients with chronic inflammatory arthritis: a randomised control trail with paired-design. - LIJO: Stands for "LIgnocaine in JOint injection"

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/01/061287
Enrollment
80
Registered
2024-01-09
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M468- Other specified inflammatory spondylopathies Health Condition 2: M059- Rheumatoid arthritis with rheumatoid factor, unspecified

Interventions

Intervention1: Lignocaine 2% + corticosteroid: Intraarticular injections of Lignocaine + corticosteroid
Lignocaine 2% 5 ml into large joints (shoulder and knee) and 2 ml into medium joints (ankle and elbow) Control Intervention1: Corticosteroid Alone: Intraarticular Corticosteroid (No added Lignocaine)

Sponsors

Department of Internal MEdicine
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Diagnosed as a case of rheumatoid arthritis or spondyloarthritis 2. Having bilateral symmetrical swollen joints - either both shoulders or knees or ankles or elbows planned for joint injections

Exclusion criteria

Exclusion criteria: 1. Patient refusal to participate in study 2. Allergy to Lignocaine or Methyl-Prednisolone acetate 3. Joints are damaged 4. Inability of the patient to be able to understand or give pain scores 5. Non-symmetrical joint involvement (Symmetry as assessed by physician) 6. Standard exclusion for any intra-articular steroids including Septic-arthritis or overlying skin infection,Coagulopathy, Joint Prosthesis, Intra-articular fracture

Design outcomes

Primary

MeasureTime frame
Improvement in joint-painTimepoint: 1-hour

Secondary

MeasureTime frame
Improvement in Joint-pain at 1-day between the IAC+LA versus IAC aloneTimepoint: 1 day;Improvement in Joint-pain at 1-week between the IAC+LA versus IAC aloneTimepoint: 1 week;Procedural pain between the IAC+LA versus IAC aloneTimepoint: immediate;Relapse rates at 3 months post intra articular injectionTimepoint: 3 months

Countries

India

Contacts

Public ContactRaveesh Bamigatti

PGIMER, Chandigarh

varundhir@gmail.com8872229998

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026