Effect of mixing ephedrine with propofol for prevention of low blood pressure on start of anaesthesia with propofol in patients undergoing emergency exploratory surgeries of the abdomen

Comparison of the incidence of hypotension on induction in patients undergoing emergency laparotomy induced with propofol alone versus propofol premixed with ephedrine - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061270

Enrollment

Registered

2024-01-09

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K566- Other and unspecified intestinal obstruction

Interventions

Intervention1: Group PE: Pre-mixing injection ephedrine at a dose of 0.1mg/kg is done with the induction dose of propofol at 1.5mg/kg (calculated dose) in an attempt to prevent hypotension on inductio

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1,2 and 3 patients presenting for emergency exploratory laparotomy for various indications at emergency theatre at Govt medical college Thiruvananthapuram

Exclusion criteria

Exclusion criteria: 1. ASA 4 and above 2. Patients on inotropic support or vasopressors for maintaining mean arterial pressure > 65mHg pressure in whom propofol induction is relatively contraindicated 3. Patients with decompensated heart disease or heart failure 4. Patients with heart rate >140/ min or 5. Anaphylaxis to propofol/ ephedrine 6. Patient /by stander refusal to participate in the study 7. Patients who are unable to give valid consent due to altered sensorium or under influence of alcohol

Design outcomes

Secondary

Measure	Time frame
intraoperative hypotension need for supports post operative hypotensionTimepoint: duration of surgery	—

Primary

Measure	Time frame
Incidence of hypotension on inductionTimepoint: 10mins after induction	—

Countries

India

Contacts

Public ContactDr Arun Kumar A

Govt Medical college Thirivananthapuram

dr.arunkumar331986@gmail.com8281414827

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026