Health Condition 1: F445- Conversion disorder with seizuresor convulsions
Conditions
Interventions
Intervention1: TRANSCRANIAL DIRECT CURRENT STIMULATION: Application of tDCS and sham stimulation to intervention arm and placebo arm respectively, for 5 days two of 20mins stimulation per day
Control
Sponsors
NONE
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria: Subjects with psychogenic non-epileptic seizures 1. Aged >18 years 2. Diagnosis of PNES by short term VEEG recording 3. >=2 events/month.
Exclusion criteria
Exclusion criteria: 1)Subjects with known epilepsy 2)Subjects with PNES who have significant intellectual disability 3)Severe psychiatric comorbidity and suicidal ideations 4)Pregnant women 5)Those with dementia, psychosis, delirium, scalp infections or lesions 6)Subjects with history of brain surgery or aneurysm clipping or electrical device implantation like pacemaker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| defined as success if â?¥ 50% reduction in event frequency at end of one month compared to baseline. Timepoint: defined as success if â?¥ 50% reduction in event frequency at end of one month compared to baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| Absolute number of events/months at the end of 1,2 & 3 months expressed as median with IQR or mean with SD. Application of 1st sessions of tDCS is considered as day 1. After 30 days from the onset of tDCS patient first time followed and subsequently at 2nd and 3rd month; Safety parameters from the ADR and self-report questionnaire as proportions; Scores on HAM-A, HAM-D, BREF-QOL, QOLIE at the end of 1, 2 and 3 months as median with IQR. Timepoint: at end of 2nd & 3rd month | — |
Countries
India
Contacts
Public ContactDr Sowmya S
Jawaharlal Institute of Postgraduate Medical Education and Research
Outcome results
None listed