To study the difference between administration of intravenous antibiotics versus intravenous antibiotics plus antibiotics at the incision site to prevent the surgical site infections.

Preoperative intravenous vs. combined intravenous plus intra-incisional antibiotic administration in the prevention of Surgical site infections. - nil

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061237

Enrollment

Registered

2024-01-08

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K35-K38- Diseases of appendix Health Condition 2: K20-K31- Diseases of esophagus, stomach and duodenum Health Condition 3: K70-K77- Diseases of liver Health Condition 4: K65-K68- Diseases of peritoneum and retroperitoneum Health Condition 5: K80-K87- Disorders of gallbladder, biliary tract and pancreas Health Condition 6: K40-K46- Hernia Health Condition 7: K50-K52- Noninfective enteritis and colitis Health Condition 8: K55-K64- Other diseases of intestines Health Condition 9

Interventions

Intervention1: Injection ceftriaxone intravenous and intra-incisional: Drug-Injection ceftriaxone Dose-1 g Route-1 g Intravenous + 1 g Subcutaneous (Total 2G) Frequency- STAT dose just before incisi

Eligibility

Inclusion criteria

Inclusion criteria: Patients giving consent to take part in the study. Patients undergoing clean open abdominal surgeries including inguinal hernia, umbilical hernia and para-umbilical hernia repairs.

Exclusion criteria

Exclusion criteria: Age of the patient less than 18 years Age more than 80 years Laparoscopic surgery. Patient with type 2 Diabetes mellitus. Patient with known history of immunodeficiency. Patient with history of taking systemic corticosteroid therapy. Presence of pre-existing systemic or local infection. Patients with strangulated or obstructed hernia. Patients developing hypersensitivity reaction for the antibiotic.

Design outcomes

Primary

Measure	Time frame
To study the effect of combining preoperative intra-incisional administration of antibiotic with intravenous antibiotic in prevention of surgical site infections.Timepoint: Post operative day 3 and then alternative day until suture removal	—

Secondary

Measure	Time frame
To compare the efficacy of preoperative combined intravenous and intra-incisional antibiotic administration with intravenous alone in prevention of Surgical site infections in abdominal surgeries.Timepoint: Post operative day 3 and then alternative day until suture removal	—

Countries

India

Contacts

Public ContactDr Manoj Togale

KLE University Jawaharlal Nehru Medical College

zapmanojtogale@gmail.com9844706266

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026