Health Condition 1: G373- Acute transverse myelitis in demyelinating disease of central nervous system
Conditions
Interventions
Intervention1: simultaneous IVMPS and PLEX group: Patients will be given
Intervention2: Simultaneous Therapy: Simultaneous IVMPS and plasma exchange will be started.IVPMS 1 gm/day will be given for 5
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patient having severe attack of myelitis. 2.MRC power in limb of grade = 2. 3.Patients meet the criteria of NMOSD.
Exclusion criteria
Exclusion criteria: Haemodynamic instability. Coagulopathy. Not giving consent for plasma exchange. Severe or uncontrolled infection. EDSS = 6 due to previous attack of NMOSD. Patient refused to consent for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the efficacy of simultaneous PLEX and IVMPS as compared to IVMPS with add on PLEX as treatment of severe attack of acute myelitis of NMOSD.Timepoint: Primary Outcome will be measured at three months of randomization. | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the efficacy of simultaneous PLEX and IVMPS as compared to IVMPS with add on PLEX, one point improvement in EDSS will be categorised as clinically meaningful improvement.Timepoint: Secondary Outcome will be measured at one and six months of randomization. | — |
Countries
India
Contacts
Public ContactDr Rajesh Kumar Singh
AIIMS
Outcome results
None listed