Study to assess the effect of a painkiller medication (Magnesium Sulphate) on the electrical activity of the nerves

Effect of Magnesium Sulphate on Motor-evoked Potentials and Somatosensory evoked potentials: An open label prospective interventional cohort study - nil

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061199

Enrollment

Registered

2024-01-08

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G94- Other disorders of brain in diseases classified elsewhere

Interventions

Intervention1: magnesium sulphate: IV magnesium sulphate 40 mg/kg single bolus dose given over 10 minutes Control Intervention1: not applicable: not applicable

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective cranial surgery who are planned for intraoperative neuromonitoring (Somatosensory evoked potentials or motor evoked potentials or both)

Exclusion criteria

Exclusion criteria: 1. Known neuromuscular disease 2. Pregnancy 3. Cardiac conduction disorders and Ischemic Heart Disease 4. Chronic Kidney Disease 5. Refusal of consent to participate in the study

Design outcomes

Primary

Measure	Time frame
Latency and amplitude of SSEP and MEPTimepoint: 1 hour during surgery	—

Secondary

Measure	Time frame
nilTimepoint: nil	—

Countries

India

Contacts

Public ContactDr Janardhanan D

National Institute of Mental Health and Neurosciences, Bangalore

drvjramesh@gmail.com9844432607

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026