None listed
Conditions
Interventions
Intervention1: Multimodal care bundle: Multimodal care bundle constitutes of regular monitoring of vascular risk factors, culturally appropriate nutritional guidance, physical exercise/yoga, and psych
Sponsors
Department of Health Research,ICMR,MOHFW, ICMR
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age more than or equal to 55 years 2. Permanent resident of the defined area 3. CAIDE (Cardiovascular Risk Factors Aging and Dementia) Risk Score of 6 points or higher 4. Absence of Dementia or MCI (DSM 5 criteria for major Neurocognitive Decline) after Neuropsychological evaluation 5. Consenting to participate and complete all study related activities for 5 years
Exclusion criteria
Exclusion criteria: 1. Established Dementia 2. Disabling stroke or structural brain abnormality 3. Vision, hearing or communication impairment affecting NP testing 4. Psychiatric illness- major depressive disorder, psychosis 5. Significant medical illness like malignancy, end stage renal disease, decompensated liver disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of all cause probable dementia or mild cognitive impairmentTimepoint: 5 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in composite and domain Z scoresTimepoint: 5 years;Change in LIBRA IndexTimepoint: 5 years;Composite outcome of stroke and MITimepoint: 5 YEARS;Composite outcome of stroke, MI, MCI, DementiaTimepoint: 5 years;Incidence of mild cognitive impairmentTimepoint: 5 years;MortalityTimepoint: 5 years;time to first occurrence of diagnosis of dementiaTimepoint: 5 years;time to first occurrence of diagnosis of MCITimepoint: 5 YEARS | — |
Countries
India
Contacts
Public ContactVishnu VY
AIIMS New Delhi
Outcome results
None listed