Comparision of nerve block with opiod in relieving pain of patients with acute pancreatitis

Comparision of efficacy of erector spinae plane block versus conventional pharmacological therapy in successfully alleviating abdominal pain of patients with pancreatitis in an emergency department: A Randomized Control Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061167

Enrollment

Registered

2024-01-05

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K859- Acute pancreatitis, unspecified Health Condition 2: 3- Administration

Interventions

Intervention1: Bilateral Erector Spinae Plane Block: Ultrasound guidance Bilateral erector spinae plane block will be done by inserting a nerve block needle with 0.5% Bupivacaine (calculated amount by

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adults patients (= 18 years of age) who are already diagnosed as acute or recurrent acute pancreatitis, presenting to the emergency department of AIIMS New Delhi within 7 days of onset of abdominal pain with DVPRS = 7. 2. Patients willing to give consent.

Exclusion criteria

Exclusion criteria: 1. Patients with hemodynamic instability 2. Patients having one or more organ dysfunction 3. Patients allergic to drugs 4. Local site infection 5. Spine deformity (both acquired or congenital) 6. Pregnancy 7. Immunosuppressive state 8. Patients with chronic kidney disease, chronic liver disease, congestive heart failure

Design outcomes

Primary

Measure	Time frame
To assess the efficacy of successful pain relief (more than 50% reduction in pain score by Defense and Veterans Pain Scale(DVPRS) from presentation or DVPRS less than 4 or total amount of rescue analgesia needed) after six hours of intervention in both ESPB arm and conventional pharmacological therapy (CPT) arm.Timepoint: Primary outcome will be assessed and analysed after six hours of intervention in both ESPB arm and conventional pharmacological therapy (CPT) arm.	—

Measure

Time frame

To assess the efficacy of successful pain relief (more than 50% reduction in pain score by Defense and Veterans Pain Scale(DVPRS) from presentation or DVPRS less than 4 or total amount of rescue analgesia needed) after six hours of intervention in both ESPB arm and conventional pharmacological therapy (CPT) arm.Timepoint: Primary outcome will be assessed and analysed after six hours of intervention in both ESPB arm and conventional pharmacological therapy (CPT) arm.

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Secondary

Measure	Time frame
Drugs or procedure related adverse events in both armTimepoint: Upto 6 hours after intervention or 24 hours if patient remains in the emergency department;Pain free interval in both arm: It will be defined as either DVPRS less than 4 or no need of rescue analgesia.Timepoint: Upto 6 hours after intervention or 24 hours if patient remains in the emergency department;Pain score assessment at different time interval (at 1 hour, 6 hours, then every 6 hours up to 24 hours)Timepoint: Upto 6 hours after intervention or 24 hours if patient remains in the emergency department;Patient feedback based on Likert scaling regarding preference of therapy he or she would opt for in next visitTimepoint: Upto 6 hours after intervention or 24 hours if patient remains in the emergency department;Timing of rescue therapy in both arm and total cumulative dose of fentanyl as rescue therapy after 12 and 24 hoursTimepoint: Upto 6 hours after intervention or 24 hours if patient remains in the emergency department	—

Measure

Time frame

Drugs or procedure related adverse events in both armTimepoint: Upto 6 hours after intervention or 24 hours if patient remains in the emergency department;Pain free interval in both arm: It will be defined as either DVPRS less than 4 or no need of rescue analgesia.Timepoint: Upto 6 hours after intervention or 24 hours if patient remains in the emergency department;Pain score assessment at different time interval (at 1 hour, 6 hours, then every 6 hours up to 24 hours)Timepoint: Upto 6 hours after intervention or 24 hours if patient remains in the emergency department;Patient feedback based on Likert scaling regarding preference of therapy he or she would opt for in next visitTimepoint: Upto 6 hours after intervention or 24 hours if patient remains in the emergency department;Timing of rescue therapy in both arm and total cumulative dose of fentanyl as rescue therapy after 12 and 24 hoursTimepoint: Upto 6 hours after intervention or 24 hours if patient remains in the emergency department

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Countries

India

Contacts

Public ContactDr Satyendra Meena

AIIMS, New Delhi

sanjeevbhoi@gmail.com8527050391

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026