Comparative study on the effectiveness of IV Inj. Dexmedetomidine and IV Inj. Magnesium sulphate on haemodynamic parameters during Laryngoscopy and intubation in patients undergoing surgery under general anaesthesia

Comparative Study on the Effect of Dexmedetomidine and Magnesium Sulphate on Haemodynamic Response during Laryngoscopy and Intubation in Patients undergoing Surgery under General Anaesthesia- A Double Blinded Randomised Control Study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/01/061158

Enrollment

Registered

2024-01-05

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: The effects of Dexmedetomidine drug on hemodynamic response during intubation.: Patients will receive IV dexmedetomidine 0.6mcg/kg diluted in 100ml NS over 10min before induction of gen

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA grade 1 and 2. 2.Age 18 to 60 years. 3.Both gender 4.Elective and emergency surgeries under general anaesthesia

Exclusion criteria

Exclusion criteria: 1. BMI >35 kg/m2 2. Pregnant women. 3.Renal or Hepatic impairment 4.Cardiopulmonary disease 5.Cardiac rhythm abnormalities –heart block 6. Allergy to drugs being used

Design outcomes

Primary

Measure	Time frame
To compare the effects of Dexmedetomidine and Magnesium sulphate on hemodynamic response during intubation.Timepoint: On entering operation theatre baseline vital Is monitored followed by 5,10 minutes from the time of test drug administration followed by 2 minutes after induction of general Anesthesia and 1,3,5,10 minutes after intubation followed by every 30 minutes till 120 minutes vitals are monitored	—

Measure

Time frame

To compare the effects of Dexmedetomidine and Magnesium sulphate on hemodynamic response during intubation.Timepoint: On entering operation theatre baseline vital Is monitored followed by 5,10 minutes from the time of test drug administration followed by 2 minutes after induction of general Anesthesia and 1,3,5,10 minutes after intubation followed by every 30 minutes till 120 minutes vitals are monitored

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Secondary

Measure	Time frame
To compare intraoperative time of requirement of first dose of muscle relaxantsTimepoint: The time of requirement of first dose of muscle relaxants based on the changes in capnography- curare notch or raise in airway pressure will be noted;To compare the effects of both drugs on hemodynamic changes during extubationTimepoint: Haemodynamic response to extubation will be recorded immediately after extubation zero minutes (E0), 1 min after extubation (E1), 5 mins after extubation (E5);To compare the effects of both drugs on post-operative sedation of the patient. Side effects if anyTimepoint: The degree of sedation will be assessed in post operative room using RAMSAY sedation scale at recovery room(0 min), after 15 mins, after 30 mins, after 60 mins and after 120 mins.	—

Measure

Time frame

To compare intraoperative time of requirement of first dose of muscle relaxantsTimepoint: The time of requirement of first dose of muscle relaxants based on the changes in capnography- curare notch or raise in airway pressure will be noted;To compare the effects of both drugs on hemodynamic changes during extubationTimepoint: Haemodynamic response to extubation will be recorded immediately after extubation zero minutes (E0), 1 min after extubation (E1), 5 mins after extubation (E5);To compare the effects of both drugs on post-operative sedation of the patient. Side effects if anyTimepoint: The degree of sedation will be assessed in post operative room using RAMSAY sedation scale at recovery room(0 min), after 15 mins, after 30 mins, after 60 mins and after 120 mins.

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Countries

India

Contacts

Public ContactKaviyarasi P

Chettinad academy of research and education

pugalenthi08@yahoo.co.in9489404818

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026