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Using the Right Dose of Gefitinib medicine for Better Treatment in Lung Cancer

Precision Therapy of Gefitinib in Non-Small Cell Lung Cancer Patients: An Integrated Pharmacogenomic and Population Pharmacokinetic Approach - NIL

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/01/061126
Enrollment
250
Registered
2024-01-04
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C343- Malignant neoplasm of lower lobe,bronchus or lung Health Condition 2: C340- Malignant neoplasm of main bronchus Health Condition 3: C342- Malignant neoplasm of middle lobe,bronchus or lung Health Condition 4: C348- Malignant neoplasm of overlappingsites of bronchus and lung Health Condition 5: C349- Malignant neoplasm of unspecifiedpart of bronchus or lung Health Condition 6: C341- Malignant neoplasm of upper lobe,bronchus or lung

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Intramural Funding, MAHE, Manipal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Non-Small Cell Lung Cancer patients (both males and females) with EGFR positive mutation. 2. Age group of 18-80 years. 3. Patients who are willing to give informed consent.

Exclusion criteria

Exclusion criteria: 1. HIV positive patients. 2. Patients with seriously ill conditions (eg: COVID 19 etc.,) or clinically unstable patients.

Design outcomes

Primary

MeasureTime frame
The current research aims to develop an appropriate gefitinib population pharmacokinetic model for deriving an individualized gefitinib dosing strategy for NSCLC patients in tertiary care hospitals.Timepoint: 3 years

Secondary

MeasureTime frame
Development of such a Population pharmacokinetic model for gefitinib will aid in the implementation of precision therapy for the management of NSCLC. Thus, this study would comprehensively analyse precision therapy of lung cancer patients in our settings.Timepoint: 3 years

Countries

India

Contacts

Public ContactMiss Prathvi V Shenoy

Manipal College of Pharmaceutical Sciences, MAHE, Manipal

mahadev.rao@manipal.edu8105706060

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026